Dylan J. M. Bergen

TL;DR: The zebrafish is outlined as a powerful model for osteoporosis research to validate potential therapeutic candidates, and the tools and assays that can be used to study bone homeostasis, and affordable (semi-)high-throughput compound testing are described.

TL;DR: The relative big size and increased cognitive capacity of rats as compared to mice will facilitate complex behavioral studies and detailed mechanistic studies regarding central function ofMC4R, both of which ultimately may help to further understand the specific mechanisms that induce obesity during loss of MC4R function.

TL;DR: It is shown that c-MYC–responsive gene Cdca7 is expressed in different HSC and progenitor subpopulations and that CDCA7 is important for maintaining the undifferentiated phenotype, indicating a highly conserved Notch/RBPj/Cdca 7 axis in hematopoietic development.

TL;DR: In this paper, the authors show that the loss of the largest golgin, giantin, leads to substantial changes in gene expression despite only limited effects on the Golgi structure.

TL;DR: Interactions between coronin-1C (Coro1C), RCC2 and Rac1 that focus active Rac1 to a single protrusion are identified, demonstrating the crucial role in migration guidance in vivo.