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Benjamin R. Sabari
Researcher at Massachusetts Institute of Technology
Publications - 26
Citations - 6011
Benjamin R. Sabari is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Histone code & Regulation of gene expression. The author has an hindex of 15, co-authored 22 publications receiving 3773 citations. Previous affiliations of Benjamin R. Sabari include Rockefeller University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Coactivator condensation at super-enhancers links phase separation and gene control
Benjamin R. Sabari,Alessandra Dall’Agnese,Ann Boija,Isaac A. Klein,Isaac A. Klein,Eliot L. Coffey,Krishna Shrinivas,Brian J. Abraham,Nancy M. Hannett,Alicia V. Zamudio,John C. Manteiga,Charles H. Li,Yang Eric Guo,Daniel S. Day,Jurian Schuijers,Eliza Vasile,Sohail Malik,Denes Hnisz,Tong Ihn Lee,Ibrahim I Cisse,Robert G. Roeder,Phillip A. Sharp,Arup K. Chakraborty,Richard A. Young +23 more
TL;DR: It is postulated that super-enhancers are phase-separated multimolecular assemblies, also known as biomolecular condensates, which provide a means to compartmentalize and concentrate biochemical reactions within cells.
Journal ArticleDOI
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Ann Boija,Isaac A. Klein,Benjamin R. Sabari,Alessandra Dall’Agnese,Eliot L. Coffey,Alicia V. Zamudio,Charles H. Li,Krishna Shrinivas,John C. Manteiga,Nancy M. Hannett,Brian J. Abraham,Lena K. Afeyan,Yang Eric Guo,Jenna K. Rimel,Charli B. Fant,Jurian Schuijers,Tong Ihn Lee,Dylan J. Taatjes,Richard A. Young +18 more
TL;DR: It is reported that diverse ADs form phase- separated condensates with the Mediator coactivator, suggesting that diverse TFs can interact with Mediator through the phase-separating capacity of their ADs and that formation of condensate with Mediation is involved in gene activation.
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Metabolic regulation of gene expression through histone acylations
TL;DR: A model is proposed to explain the present understanding of how differential histone acylation is regulated by the metabolism of the different acyl-CoA forms, which in turn modulates the regulation of gene expression.
Journal ArticleDOI
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
Yang Eric Guo,John C. Manteiga,Jonathan E. Henninger,Benjamin R. Sabari,Alessandra Dall’Agnese,Nancy M. Hannett,Jan-Hendrik Spille,Jan-Hendrik Spille,Lena K. Afeyan,Alicia V. Zamudio,Krishna Shrinivas,Brian J. Abraham,Brian J. Abraham,Ann Boija,Tim-Michael Decker,Jenna K. Rimel,Charli B. Fant,Tong Ihn Lee,Ibrahim I Cisse,Phillip A. Sharp,Dylan J. Taatjes,Richard A. Young +21 more
TL;DR: In this paper, the authors investigated whether the phosphorylation of the C-terminal domain of the RNA polymerase II (PolII) C-interaction subunit regulates the incorporation of Pol II into phase-separated condensates that are associated with transcription initiation and splicing.
Journal ArticleDOI
Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation
Benjamin R. Sabari,Zhanyun Tang,He Huang,Vladimir Yong-Gonzalez,Henrik Molina,Ha Eun Kong,Lunzhi Dai,Miho Shimada,Justin R. Cross,Yingming Zhao,Robert G. Roeder,C. David Allis +11 more
TL;DR: The findings support a general principle wherein differential histone acylation couples cellular metabolism to the regulation of gene expression, and that the coactivator p300 has both crotonyl transferase and acetyltransferase activities.