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Alessandra Dall’Agnese
Researcher at Massachusetts Institute of Technology
Publications - 38
Citations - 4380
Alessandra Dall’Agnese is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Transcription factor & Enhancer. The author has an hindex of 17, co-authored 29 publications receiving 2550 citations. Previous affiliations of Alessandra Dall’Agnese include Sanford-Burnham Institute for Medical Research & University of Udine.
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Journal ArticleDOI
Coactivator condensation at super-enhancers links phase separation and gene control
Benjamin R. Sabari,Alessandra Dall’Agnese,Ann Boija,Isaac A. Klein,Isaac A. Klein,Eliot L. Coffey,Krishna Shrinivas,Brian J. Abraham,Nancy M. Hannett,Alicia V. Zamudio,John C. Manteiga,Charles H. Li,Yang Eric Guo,Daniel S. Day,Jurian Schuijers,Eliza Vasile,Sohail Malik,Denes Hnisz,Tong Ihn Lee,Ibrahim I Cisse,Robert G. Roeder,Phillip A. Sharp,Arup K. Chakraborty,Richard A. Young +23 more
TL;DR: It is postulated that super-enhancers are phase-separated multimolecular assemblies, also known as biomolecular condensates, which provide a means to compartmentalize and concentrate biochemical reactions within cells.
Journal ArticleDOI
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Ann Boija,Isaac A. Klein,Benjamin R. Sabari,Alessandra Dall’Agnese,Eliot L. Coffey,Alicia V. Zamudio,Charles H. Li,Krishna Shrinivas,John C. Manteiga,Nancy M. Hannett,Brian J. Abraham,Lena K. Afeyan,Yang Eric Guo,Jenna K. Rimel,Charli B. Fant,Jurian Schuijers,Tong Ihn Lee,Dylan J. Taatjes,Richard A. Young +18 more
TL;DR: It is reported that diverse ADs form phase- separated condensates with the Mediator coactivator, suggesting that diverse TFs can interact with Mediator through the phase-separating capacity of their ADs and that formation of condensate with Mediation is involved in gene activation.
Journal ArticleDOI
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
Yang Eric Guo,John C. Manteiga,Jonathan E. Henninger,Benjamin R. Sabari,Alessandra Dall’Agnese,Nancy M. Hannett,Jan-Hendrik Spille,Jan-Hendrik Spille,Lena K. Afeyan,Alicia V. Zamudio,Krishna Shrinivas,Brian J. Abraham,Brian J. Abraham,Ann Boija,Tim-Michael Decker,Jenna K. Rimel,Charli B. Fant,Tong Ihn Lee,Ibrahim I Cisse,Phillip A. Sharp,Dylan J. Taatjes,Richard A. Young +21 more
TL;DR: In this paper, the authors investigated whether the phosphorylation of the C-terminal domain of the RNA polymerase II (PolII) C-interaction subunit regulates the incorporation of Pol II into phase-separated condensates that are associated with transcription initiation and splicing.
Journal ArticleDOI
Partitioning of Cancer Therapeutics in Nuclear Condensates
Isaac A. Klein,Isaac A. Klein,Ann Boija,Lena K. Afeyan,Susana Wilson Hawken,Mengyang Fan,Alessandra Dall’Agnese,Ozgur Oksuz,Jonathan E. Henninger,Krishna Shrinivas,Benjamin R. Sabari,Ido Sagi,Victoria E. Clark,Victoria E. Clark,Jesse M. Platt,Jesse M. Platt,Mrityunjoy Kar,Patrick M. McCall,Alicia V. Zamudio,John C. Manteiga,Eliot L. Coffey,Charles H. Li,Nancy M. Hannett,Yang Eric Guo,Tim-Michael Decker,Tong Ihn Lee,Tinghu Zhang,Jing-Ke Weng,Dylan J. Taatjes,Arup K. Chakraborty,Phillip A. Sharp,Young-Tae Chang,Anthony A. Hyman,Anthony A. Hyman,Nathanael S. Gray,Richard A. Young +35 more
TL;DR: It is found that antineoplastic drugs become concentrated in specific protein condensates in vitro and that this occurs through physicochemical properties independent of the drug target, which suggests that selective partitioning and concentration of small molecules within condensate contributes to drug pharmacodynamics.
Journal ArticleDOI
Biomolecular Condensates in the Nucleus.
TL;DR: The shared features of nuclear condensate, the components that produce locus-specific condensates, elements of specificity, and the emerging understanding of mechanisms regulating these compartments are described.