A
Alexander Viardot
Researcher at Garvan Institute of Medical Research
Publications - 30
Citations - 3291
Alexander Viardot is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Diabetes mellitus & Insulin resistance. The author has an hindex of 17, co-authored 28 publications receiving 2554 citations. Previous affiliations of Alexander Viardot include University of New South Wales & St. Vincent's Health System.
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Journal ArticleDOI
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Gary Frost,Michelle L. Sleeth,Meliz Sahuri-Arisoylu,Blanca Lizarbe,Sebastián Cerdán,Leigh Brody,Jelena Anastasovska,Samar Ghourab,Mohammed K. Hankir,Shuai Zhang,David Carling,Jonathan R. Swann,Glenn R. Gibson,Alexander Viardot,Douglas J. Morrison,E. Louise Thomas,Jimmy D. Bell +16 more
TL;DR: It is demonstrated through 13C high-resolution magic-angle-spinning that 13C acetate from fermentation of 13C-labelled carbohydrate in the colon increases hypothalamic 13Cacetate above baseline levels, suggesting that acetate has a direct role in central appetite regulation.
Journal ArticleDOI
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
Edward S. Chambers,Alexander Viardot,Arianna Psichas,Douglas J. Morrison,Kevin G Murphy,Sagen Zac-Varghese,Kenneth MacDougall,Tom Preston,Catriona Tedford,Graham Finlayson,John E. Blundell,Jimmy D. Bell,E. Louise Thomas,Shahrul Mt-Isa,Deborah Ashby,Glen R. Gibson,Sofia Kolida,Walijit S. Dhillo,Stephen R. Bloom,Wayne Morley,Stuart Clegg,Gary Frost +21 more
TL;DR: It is demonstrated for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.
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Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia.
Tricia Tan,Benjamin C. T. Field,Katherine McCullough,Rachel C. Troke,Edward S. Chambers,Victoria Salem,Juan Gonzalez Maffe,Kevin C.R. Baynes,Akila De Silva,Alexander Viardot,Ali Alsafi,Gary Frost,Mohammad A. Ghatei,Stephen R. Bloom +13 more
TL;DR: The data indicate that drugs with glucagon and GLP-1 agonist activity may represent a useful treatment for type 2 diabetes and obesity, and long-term studies are required to demonstrate that this combination will reduce weight and improve glycemia in patients.
Journal ArticleDOI
Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test
TL;DR: Based on its remarkable reproducibility, easy noninvasive nature, and at least similar diagnostic performance, NSC appears to be a preferable alternative to 24-h UFC as a first-line screening test for Cushing's syndrome.
Journal ArticleDOI
Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype.
TL;DR: It is demonstrated for the first time that insulin treatment influences T cell differentiation promoting a shift toward a Th2-type response, which may contribute to its antiinflammatory role not only in sepsis, but also in chronic inflammation associated with obesity and type 2 diabetes.