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Edith Bonnelye
Researcher at French Institute of Health and Medical Research
Publications - 49
Citations - 3160
Edith Bonnelye is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Bone metastasis & Cancer. The author has an hindex of 23, co-authored 45 publications receiving 2713 citations. Previous affiliations of Edith Bonnelye include University of Lyon & Claude Bernard University Lyon 1.
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Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
TL;DR: In vitro assays performed on primary murine bone cells confirmed the dual action of strontium ranelate in vivo as an anabolic agent on bone remodeling, which stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization.
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The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates.
Ngoc Vu-Dac,Sandrine Chopin-Delannoy,Philippe Gervois,Edith Bonnelye,Geneviève Martin,Jean-Charles Fruchart,Vincent Laudet,Bart Staels +7 more
TL;DR: The opposite regulation of rat and human apoA-I gene expression by fibrates is linked to differences in cis-elements in their respective promoters leading to repression by Rev-erbα of rat apo A-I and activation by PPARα of human api-I.
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A Cathepsin K Inhibitor Reduces Breast Cancer–Induced Osteolysis and Skeletal Tumor Burden
Céline Le Gall,Akeila Bellahcene,Edith Bonnelye,Jürg A. Gasser,Vincent Castronovo,Jonathan Green,Johann Zimmermann,Philippe Clézardin +7 more
TL;DR: Findings raise the possibility that cathepsin K could be a therapeutic target for the treatment of bone metastases by rendering the bone a less favorable microenvironment for tumor growth by inhibiting bone resorption.
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Actin cytoskeletal organisation in osteoclasts: A model to decipher transmigration and matrix degradation
TL;DR: The dynamic actin remodelling in osteoclasts appears then as a major factor to understand their unusual abilities reminiscent of metastatic tumour cells.
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The ERR-1 orphan receptor is a transcriptional activator expressed during bone development.
Edith Bonnelye,Jean Marc Vanacker,Tanja Dittmar,Agnes Begue,Xavier Desbiens,David T. Denhardt,Jane E. Aubin,Vincent Laudet,Brigitte Fournier +8 more
TL;DR: A role for ERR-1 in bone development and metabolism is suggested and it is found that both the core AGGTCA motif and the TCA 5'-extension are required for efficient ERr-1 binding.