Pierre Jurdic

TL;DR: In vitro assays performed on primary murine bone cells confirmed the dual action of strontium ranelate in vivo as an anabolic agent on bone remodeling, which stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization.

TL;DR: The data show that the impact of Snail1 activity on the osteoblast population regulates the course of bone cells differentiation and ensures normal bone remodelling.

TL;DR: GDF-15 inhibits expression of carbonic anhydrase II and cathepsin K, key osteoclast enzymes, and induces changes in SMAD and p38 signaling, and the lack of functional osteoclasts can contribute to accumulation of bone matrix by reduction of bone resorption.

TL;DR: The data suggest that TRβ receptors mediate the acute effects produced by transient changes of TH concentrations on bone remodeling, whereas TRα receptorsMediate long‐term effects of chronic alterations of TH metabolism, shed new light on the respective roles of TRs in the control of bone metabolism by TH.

TL;DR: It is observed that podosome rings generate tension forces and that osteoclasts migrate by periodically moving toward the actin-containing structures, and actin dynamics thus not only correlate with the cell migration, but drive it.