Edith Bonnelye

TL;DR: In vitro assays performed on primary murine bone cells confirmed the dual action of strontium ranelate in vivo as an anabolic agent on bone remodeling, which stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization.

TL;DR: The opposite regulation of rat and human apoA-I gene expression by fibrates is linked to differences in cis-elements in their respective promoters leading to repression by Rev-erbα of rat apo A-I and activation by PPARα of human api-I.

TL;DR: Findings raise the possibility that cathepsin K could be a therapeutic target for the treatment of bone metastases by rendering the bone a less favorable microenvironment for tumor growth by inhibiting bone resorption.

TL;DR: The dynamic actin remodelling in osteoclasts appears then as a major factor to understand their unusual abilities reminiscent of metastatic tumour cells.

TL;DR: A role for ERR-1 in bone development and metabolism is suggested and it is found that both the core AGGTCA motif and the TCA 5'-extension are required for efficient ERr-1 binding.