E
Edward M. Tilmont
Researcher at National Institutes of Health
Publications - 17
Citations - 2625
Edward M. Tilmont is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Calorie restriction & Lean body mass. The author has an hindex of 15, co-authored 17 publications receiving 2442 citations.
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Journal ArticleDOI
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Julie A. Mattison,George S. Roth,T. Mark Beasley,Edward M. Tilmont,April M. Handy,April M. Handy,Richard Herbert,Dan L. Longo,David B. Allison,Jennifer E. Young,Mark Bryant,Dennis Barnard,Walter F. Ward,Wenbo Qi,Donald K. Ingram,Rafael de Cabo +15 more
TL;DR: A separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate is suggested.
Journal ArticleDOI
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
Navin Maswood,Jennifer E. Young,Edward M. Tilmont,Zhiming Zhang,Don M. Gash,Greg A. Gerhardt,Richard Grondin,George S. Roth,Julie A. Mattison,Mark A. Lane,Richard E. Carson,Robert M. Cohen,Peter R. Mouton,Christopher Quigley,Mark P. Mattson,Donald K. Ingram +15 more
TL;DR: It is reported that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease and levels of glial cell line-derived neurotrophic factor were increased significantly in the caudate nucleus of CR monkeys, suggesting a role for glialcell line- derived neurotrophic factors in the anti-Parkinson's disease effect of the low-Calorie diet.
Journal ArticleDOI
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents
Mark A. Lane,David J. Baer,William V. Rumpler,Richard Weindruch,Donald K. Ingram,Edward M. Tilmont,Richard G. Cutler,George S. Roth +7 more
TL;DR: Reductions in body temperature and energy expenditure are consistent with findings in rodent studies in which aging rate was retarded by CR, strengthening the possibility that CR may exert beneficial effects in primates analogous to those observed in rodents.
Journal ArticleDOI
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet
Yolanda Jimenez-Gomez,Julie A. Mattison,Kevin J. Pearson,Kevin J. Pearson,Alejandro Martin-Montalvo,Hector H. Palacios,Alex M. Sossong,Theresa M. Ward,Caitlin M. Younts,Kaitlyn N. Lewis,Joanne S. Allard,Joanne S. Allard,Dan L. Longo,Jonathan P. Belman,María M. Malagón,Plácido Navas,Mitesh Sanghvi,Ruin Moaddel,Edward M. Tilmont,Richard Herbert,Christopher H. Morrell,Josephine M. Egan,Joseph A. Baur,Luigi Ferrucci,Jonathan S. Bogan,Michel Bernier,Rafael de Cabo +26 more
TL;DR: Chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys, which is associated with a chronic, low-grade, systemic inflammation.
Journal ArticleDOI
Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.
Julie A. Mattison,Mingyi Wang,Michel Bernier,Jing Zhang,Sung-Soo Park,Stuart Maudsley,Steven S. An,Lakshmi Santhanam,Bronwen Martin,Shakeela Faulkner,Christopher H. Morrell,Christopher H. Morrell,Joseph A. Baur,Leonid Peshkin,Danuta Sosnowska,Anna Csiszar,Richard Herbert,Edward M. Tilmont,Zoltan Ungvari,Kevin J. Pearson,Edward G. Lakatta,Rafael de Cabo +21 more
TL;DR: In rhesus monkeys, a 2 year diet high in fat and sucrose increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation, and dietary resveratrol prevented the HFS-inducedarterial wall inflammation and the accompanying increase in PWV.