Edward S. Chen

TL;DR: The panel used systematic reviews of the evidence to inform clinical recommendations in favor of or against various diagnostic tests in patients with suspected or known sarcoidosis.

TL;DR: A limited proteomics approach was used to detect tissue antigens that were poorly soluble in neutral detergent and resistant to protease digestion, consistent with the known biochemical properties of granuloma-inducing sarcoidosis tissue extracts, and Matrix-assisted laser desorption/ionization time of flight mass spectrometry identified Mycobacterium tuberculosis catalase–peroxidase (mKatG) as one of these tissue antIGens.

TL;DR: The lung is altered in emphysema such that the Type II pneumocyte secretes MMP-1 and the induction of a proteolytic enzyme within the Type 2 pneumocyte suggests that the cells within the lung itself are capable of producing degradative enzymes in this disease process.

TL;DR: Serum amyloid A is a constituent and innate regulator of granulomatous inflammation in sarcoidosis through Toll-like receptor-2, providing a mechanism for chronic disease and new therapeutic targets.

TL;DR: This research presents a meta-analyses of the determinants of coronary heart disease and stroke in mice and shows clear patterns of disease progression that are consistent with those seen in animals and humans.