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Edward S. Lein
Researcher at Allen Institute for Brain Science
Publications - 10
Citations - 3053
Edward S. Lein is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Hippocampal formation & Dentate gyrus. The author has an hindex of 10, co-authored 10 publications receiving 2789 citations. Previous affiliations of Edward S. Lein include Salk Institute for Biological Studies.
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Journal ArticleDOI
Wnt signalling regulates adult hippocampal neurogenesis
Dieter Chichung Lie,Sophia A. Colamarino,Hongjun Song,Hongjun Song,Laurent Désiré,Helena Mira,Antonella Consiglio,Edward S. Lein,Sebastian Jessberger,Heather Lansford,Alejandro R. Dearie,Fred H. Gage +11 more
TL;DR: It is shown that adult hippocampal stem/progenitor cells (AHPs) express receptors and signalling components for Wnt proteins, which are key regulators of neural stem cell behaviour in embryonic development, and that the Wnt/β-catenin pathway is active and that Wnt3 is expressed in the hippocampal neurogenic niche.
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Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
Xinyu Zhao,Tetsuya Ueba,Tetsuya Ueba,Brian R. Christie,Basam Z. Barkho,Michael J. McConnell,Kinichi Nakashima,Edward S. Lein,Brennan D. Eadie,Andrew R. Willhoite,Alysson R. Muotri,Robert G. Summers,Jerold Chun,Kuo-Fen Lee,Fred H. Gage +14 more
TL;DR: It is found that MBD1-/- neural stem cells exhibited reduced neuronal differentiation and increased genomic instability, which indicates that DNA methylation is important in maintaining cellular genomic stability and is crucial for normal neural stem cell and brain functions.
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Adolescent mental health—Opportunity and obligation
Francis S. Lee,Hakon Heimer,Jay N. Giedd,Edward S. Lein,Nenad Sestan,Daniel R. Weinberger,B. J. Casey +6 more
TL;DR: This is a peak time for clinical onset of most mental illnesses and the highest single source of global economic burden in the world for mental health costs.
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Transcriptional profiling reveals strict boundaries between hippocampal subregions.
TL;DR: The conclusion that there is a molecular basis for the previously defined anatomic subregions of the hippocampus is supported and genes that could be important in defining the unique functions of the hippocampal subfields are revealed.
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A genetic method for selective and quickly reversible silencing of mammalian neurons
TL;DR: The rapid and reversible inactivation of mammalian cortical neurons expressing the insect G-protein-coupled receptor AlstR after application of its peptide ligand allatostatin (AL) could be achieved rapidly, within minutes.