D
Dieter Chichung Lie
Researcher at University of Erlangen-Nuremberg
Publications - 25
Citations - 3237
Dieter Chichung Lie is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 14, co-authored 25 publications receiving 2886 citations. Previous affiliations of Dieter Chichung Lie include Salk Institute for Biological Studies.
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Journal ArticleDOI
Wnt signalling regulates adult hippocampal neurogenesis
Dieter Chichung Lie,Sophia A. Colamarino,Hongjun Song,Hongjun Song,Laurent Désiré,Helena Mira,Antonella Consiglio,Edward S. Lein,Sebastian Jessberger,Heather Lansford,Alejandro R. Dearie,Fred H. Gage +11 more
TL;DR: It is shown that adult hippocampal stem/progenitor cells (AHPs) express receptors and signalling components for Wnt proteins, which are key regulators of neural stem cell behaviour in embryonic development, and that the Wnt/β-catenin pathway is active and that Wnt3 is expressed in the hippocampal neurogenic niche.
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Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
Tomoko Kuwabara,Jenny Hsieh,Alysson R. Muotri,Gene W. Yeo,Masaki Warashina,Masaki Warashina,Dieter Chichung Lie,Lynne Moore,Kinichi Nakashima,Makoto Asashima,Fred H. Gage +10 more
TL;DR: A previously unknown Wnt-mediated regulatory mechanism that simultaneously coordinates activation of NeuroD1 and LINE-1 is described, which is important for adult neurogenesis and survival of neuronal progenitors.
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Cell fusion-independent differentiation of neural stem cells to the endothelial lineage
Andrew E. Wurmser,Kinichi Nakashima,Kinichi Nakashima,Robert G. Summers,Nicolas Toni,Kevin A. D'Amour,Dieter Chichung Lie,Fred H. Gage +7 more
TL;DR: Co-cultured mouse neural stem cells with human endothelial cells revealed that NSCs had differentiated into endothelial-like cells independently of cell fusion, concluding that stem-cell plasticity is a true characteristic of N SCs and that the conversion of Nscs to unanticipated cell types can be accomplished without cell fusion.
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Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
Georgia Minakaki,Stefanie Menges,Ágnes Kittel,Evangelia Emmanouilidou,Iris Schaeffner,Katalin Barkovits,Anna Bergmann,Edward Rockenstein,Anthony Adame,Franz Marxreiter,Brit Mollenhauer,Douglas Galasko,Edit I. Buzás,Ursula Schlötzer-Schrehardt,Katrin Marcus,Wei Xiang,Dieter Chichung Lie,Kostas Vekrellis,Eliezer Masliah,Jürgen Winkler,Jochen Klucken +20 more
TL;DR: Competing evidence is provided that a) ALP inhibition increases SNCA in neuronal EVs, b) distinct ALP components are present in EVs, and c) CSF EVs transfer S NCA from cell to cell in vivo is provided.
Journal ArticleDOI
Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus.
Elias Gebara,Michael A. Bonaguidi,Ruth Beckervordersandforth,Sébastien Sultan,Florian Udry,Pieter Jan Gijs,Dieter Chichung Lie,Guo Li Ming,Hongjun Song,Nicolas Toni +9 more
TL;DR: The results reveal that the adult subgranular zone of the dentate gyrus harbors two functionally different RGL cells, which can be distinguished by simple morphological criteria, supporting a morphofunctional role of their thin cellular processes.