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George R. Washko
Researcher at Brigham and Women's Hospital
Publications - 412
Citations - 20157
George R. Washko is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: COPD & Medicine. The author has an hindex of 68, co-authored 357 publications receiving 15777 citations. Previous affiliations of George R. Washko include Beth Israel Deaconess Medical Center & University of Kentucky.
Papers
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Journal ArticleDOI
Azithromycin for Prevention of Exacerbations of COPD
Richard K. Albert,Richard K. Albert,John E. Connett,William C. Bailey,Richard Casaburi,J. Allen D. Cooper,Gerard J. Criner,Jeffrey L. Curtis,Mark T. Dransfield,MeiLan K. Han,Stephen C. Lazarus,Barry J. Make,Nathaniel Marchetti,Fernando J. Martinez,Nancy E. Madinger,Charlene McEvoy,Dennis E. Niewoehner,Janos Porsasz,Connie S. Price,Connie S. Price,John J. Reilly,Paul D. Scanlon,Frank C. Sciurba,Steven M. Scharf,George R. Washko,Prescott G. Woodruff,Nicholas R. Anthonisen +26 more
TL;DR: Among selected subjects with COPD, azithromycin taken daily for 1 year, when added to usual treatment, decreased the frequency of exacerbations and improved quality of life but caused hearing decrements in a small percentage of subjects.
Journal ArticleDOI
Chronic obstructive pulmonary disease phenotypes: the future of COPD.
MeiLan K. Han,Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Gerard J. Criner,Jeffrey L. Curtis,Leonardo M. Fabbri,Jonathan G. Goldin,Paul W. Jones,William MacNee,Barry J. Make,Klaus F. Rabe,Stephen I. Rennard,Frank C. Sciurba,Edwin K. Silverman,Jørgen Vestbo,George R. Washko,Emiel F.M. Wouters,Fernando J. Martinez +18 more
TL;DR: This work proposes the following variation on this definition of COPD phenotypes: "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death)."
Journal ArticleDOI
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.
Taylor Adams,Jonas C. Schupp,Sergio Poli,Ehab A. Ayaub,Nir Neumark,Farida Ahangari,Sarah G. Chu,Benjamin A. Raby,Benjamin A. Raby,Giuseppe DeIuliis,Michael Januszyk,Qiaonan Duan,Heather A. Arnett,Asim Siddiqui,George R. Washko,Robert J. Homer,Xiting Yan,Ivan O. Rosas,Naftali Kaminski +18 more
TL;DR: A single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, is provided by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 chronic obstructive pulmonary disease (COPD) lungs.
Journal ArticleDOI
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
Kenji Mizumura,Kenji Mizumura,Kenji Mizumura,Suzanne M. Cloonan,Suzanne M. Cloonan,Kiichi Nakahira,Kiichi Nakahira,Abhiram R. Bhashyam,Morgan Cervo,Tohru Kitada,Kimberly Glass,Caroline A. Owen,Ashfaq Mahmood,George R. Washko,Shu Hashimoto,Stefan W. Ryter,Stefan W. Ryter,Augustine M.K. Choi +17 more
TL;DR: It is demonstrated that CS causes mitochondrial dysfunction that is associated with a reduction of mitochondrial membrane potential and implicate mitophagy-dependent necroptosis in lung emphysematous changes in response to CS exposure, suggesting that this pathway is a therapeutic target for COPD.
Journal ArticleDOI
Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities
George R. Washko,Gary M. Hunninghake,Isis E. Fernandez,Mizuki Nishino,Yuka Okajima,Tsuneo Yamashiro,James C. Ross,Raúl San José Estépar,David A. Lynch,John Brehm,Katherine P. Andriole,Alejandro A. Diaz,Ramin Khorasani,Katherine D'Aco,Frank C. Sciurba,Edwin K. Silverman,Hiroto Hatabu,Ivan O. Rosas +17 more
TL;DR: In smokers, interstitial lung abnormalities were associated with reduced total lung capacity and a lesser amount of emphysema and were positively associated with both greater exposure to tobacco smoke and current smoking.