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Eftychia Apostolou
Researcher at Cornell University
Publications - 2
Citations - 141
Eftychia Apostolou is an academic researcher from Cornell University. The author has contributed to research in topics: Histone H1 & Regulation of gene expression. The author has an hindex of 2, co-authored 2 publications receiving 53 citations.
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Journal ArticleDOI
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
Nevin Yusufova,Andreas Kloetgen,Matt Teater,Adewola Osunsade,Jeannie M. Camarillo,Christopher R. Chin,Ashley S. Doane,Bryan J. Venters,Stephanie Portillo-Ledesma,Joseph Conway,Jude M. Phillip,Olivier Elemento,David Scott,Wendy Béguelin,Jonathan D. Licht,Neil L. Kelleher,Louis M. Staudt,Arthur I. Skoultchi,Michael-Christopher Keogh,Eftychia Apostolou,Christopher E. Mason,Marcin Imielinski,Tamar Schlick,Tamar Schlick,Tamar Schlick,Yael David,Aristotelis Tsirigos,C. David Allis,Alexey A. Soshnev,Ethel Cesarman,Ari Melnick +30 more
TL;DR: The data indicate that H1 proteins are normally required to sequester early developmental genes into architecturally inaccessible genomic compartments and establish H1 as a bona fide tumour suppressor, and mutations in H1 drive malignant transformation primarily through three-dimensional genome reorganization, which leads to epigenetic reprogramming and derepression of developmentally silenced genes.
Journal ArticleDOI
F-Class Cells: New Routes and Destinations for Induced Pluripotency
TL;DR: An alternative pluripotent state that is dependent on continuous high levels of exogenous reprogramming factor expression is described and a comprehensive effort to molecularly compare the acquisition of this state to induced pluripotency aims at providing new insights into the mechanisms underlying cellular reprograming.