E
Ehtesham Jameel
Researcher at B. R. Ambedkar Bihar University
Publications - 17
Citations - 675
Ehtesham Jameel is an academic researcher from B. R. Ambedkar Bihar University. The author has contributed to research in topics: Protein kinase A & Docking (molecular). The author has an hindex of 10, co-authored 15 publications receiving 465 citations. Previous affiliations of Ehtesham Jameel include Jamia Millia Islamia & Zhejiang University.
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Journal ArticleDOI
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents
Ehtesham Jameel,Poonam Meena,Mudasir Maqbool,Jitendra Kumar,Waqar Ahmed,Syed Mumtazuddin,Manisha Tiwari,Nasimul Hoda,Bhyravabhotla Jayaram +8 more
TL;DR: The multitarget profile exerted by these novel triazine molecules qualified them as potential anti-Alzheimer drug candidates in AD therapy and possess very low toxic effects in the primarily pharmacokinetic study.
Journal ArticleDOI
Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.
Mudasir Maqbool,Apra Manral,Ehtesham Jameel,Jitendra Kumar,Vikas Saini,Ashutosh Shandilya,Manisha Tiwari,Nasimul Hoda,Bhyravabhotla Jayaram +8 more
TL;DR: Results from neuroprotection studies of most potent compounds 4d and 4h indicate that these derivatives can reduce neuronal death induced by H2O2-mediated oxidative stress and Aβ1-42 induced cytotoxicity.
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Structure guided design of potential inhibitors of human calcium-calmodulin dependent protein kinase IV containing pyrimidine scaffold.
Huma Naz,Ehtesham Jameel,Nasimul Hoda,Ashutosh Shandilya,Parvez Khan,Asimul Islam,Faizan Ahmad,Bhyravabhotla Jayaram,Md. Imtaiyaz Hassan +8 more
TL;DR: Some important observations are revealed to generate an improved pyrimidine based compound that holds promise as a therapeutic agent for the treatment of cancer and neurodegenerative diseases.
Journal ArticleDOI
Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV.
Ehtesham Jameel,Huma Naz,Parvez Khan,Mohd Tarique,Jitendra Kumar,Syed Mumtazuddin,Shahzaib Ahamad,Asimul Islam,Faizan Ahmad,Nasimul Hoda,Md. Imtaiyaz Hassan +10 more
TL;DR: In this article, seven pyrimidine substituted novel inhibitors of CAMKIV have been designed, synthesized and extensively characterized (ESI-MS, 1H NMR and 13C NMR studies).
Journal ArticleDOI
Pyrimidine-Triazolopyrimidine and Pyrimidine-Pyridine Hybrids as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease
Jitendra Kumar,Asim Gill,Marziya Shaikh,Anju Singh,Ashutosh Shandilya,Ehtesham Jameel,Nitin Sharma,Nirotpal Mrinal,Nasimul Hoda,Bhyravabhotla Jayaram +9 more