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Ekaterina Minskaia
Researcher at Queen's University Belfast
Publications - 4
Citations - 616
Ekaterina Minskaia is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: RNA-dependent RNA polymerase & Medicine. The author has an hindex of 2, co-authored 2 publications receiving 492 citations. Previous affiliations of Ekaterina Minskaia include University of Würzburg.
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Journal ArticleDOI
Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis
Ekaterina Minskaia,Tobias Hertzig,Alexander E. Gorbalenya,Alexander E. Gorbalenya,Valérie Campanacci,Christian Cambillau,Bruno Canard,Bruno Canard,John Ziebuhr +8 more
TL;DR: The study identifies an RNA virus ExoN activity that is involved in the synthesis of multiple RNAs from the exceptionally large genomic RNA templates of CoVs.
Journal ArticleDOI
Human Coronavirus 229E Papain-Like Proteases Have Overlapping Specificities but Distinct Functions in Viral Replication
John Ziebuhr,Barbara Schelle,Nadja Karl,Nadja Karl,Ekaterina Minskaia,Sonja Bayer,Stuart G. Siddell,Alexander E. Gorbalenya,Volker Thiel +8 more
TL;DR: The data suggest that the two HCoV-229E PLpro paralogs have overlapping substrate specificities but different functions in viral replication, and within the tightly controlled interplay of the two protease activities, PL2pro plays a universal and essential proteolytic role that appears to be assisted by the PL1 Pro paralog at specific sites.
Journal ArticleDOI
Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria
Vanessa Daza-Cajigal,Adriana S. Albuquerque,D. F. Young,Michael J. Ciancanelli,Dale Moulding,Ivan Angulo,Valentine Jeanne-Julien,Jérémie Rosain,Ekaterina Minskaia,Jean-Laurent Casanova,Stéphanie Boisson-Dupuis,Jacinta Bustamante,Richard E. Randall,Timothy D. McHugh,Adrian J. Thrasher,Siobhan O. Burns +15 more
TL;DR: The data suggests that partial JAK1 deficiency predominantly affects susceptibility to mycobacterial infection through impact on the IFN-γ responsive pathway in myeloid cells.
Journal ArticleDOI
Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma.
Ekaterina Minskaia,Jesmeen Maimaris,Adriana S. Albuquerque,Ying Hong,Despina Eleftheriou,Kimberly Gilmour,Richard Grace,Fernando Moreira,Bodo Grimbacher,Emma C. Morris,Siobhan O. Burns +10 more
TL;DR: In this article , the authors identified a novel heterozygous germline mutation STAT6 c.D419H leading to overactivity of IL-4 JAK/STAT signalling pathway, in a kindred affected by early-onset atopic dermatitis, food allergy, eosinophilic asthma, anaphylaxis and follicular lymphoma.