M
Michael J. Ciancanelli
Researcher at Rockefeller University
Publications - 32
Citations - 4330
Michael J. Ciancanelli is an academic researcher from Rockefeller University. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 25, co-authored 31 publications receiving 3375 citations. Previous affiliations of Michael J. Ciancanelli include Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
A three-dimensional model of human lung development and disease from pluripotent stem cells
Ya-Wen Chen,Sarah X.L. Huang,Ana Luisa Rodrigues Toste de Carvalho,Siu-Hong Ho,Mohammad Naimul Islam,Stefano Volpi,Stefano Volpi,Luigi D. Notarangelo,Michael J. Ciancanelli,Jean-Laurent Casanova,Jahar Bhattacharya,Alice F. Liang,Laura M. Palermo,Matteo Porotto,Anne Moscona,Hans-Willem Snoeck +15 more
TL;DR: Generation from hPSCs of lung bud organoids that contain mesoderm and pulmonary endoderm develop into branching airway and early alveolar structures after xenotransplantation and in Matrigel 3D culture and may provide a useful tool to model lung disease.
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Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
Michael J. Ciancanelli,Sarah X.L. Huang,Priya Luthra,Hannah Garner,Yuval Itan,Stefano Volpi,Stefano Volpi,Fabien G. Lafaille,Céline Trouillet,Mirco Schmolke,Randy A. Albrecht,Elisabeth Israelsson,Hye Kyung Lim,Melina Casadio,Tamar Hermesh,Lazaro Lorenzo,Lazaro Lorenzo,Lawrence W. Leung,Vincent Pedergnana,Vincent Pedergnana,Bertrand Boisson,Satoshi Okada,Satoshi Okada,Capucine Picard,Benedicte Ringuier,Françoise Troussier,Damien Chaussabel,Damien Chaussabel,Laurent Abel,Laurent Abel,Laurent Abel,Isabelle Pellier,Luigi D. Notarangelo,Adolfo García-Sastre,Christopher F. Basler,Frederic Geissmann,Shen-Ying Zhang,Shen-Ying Zhang,Shen-Ying Zhang,Hans-Willem Snoeck,Jean-Laurent Casanova +40 more
TL;DR: It is suggested that IRF7-dependent amplification of type I and III IFNs is required for protection against primary infection by influenza virus in humans and that severe influenza may result from single-gene inborn errors of immunity.
Journal ArticleDOI
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
Fabien G. Lafaille,Itai M. Pessach,Itai M. Pessach,Shen-Ying Zhang,Shen-Ying Zhang,Michael J. Ciancanelli,Melina Herman,Melina Herman,Avinash Abhyankar,Shui-Wang Ying,Sotirios Keros,Peter A. Goldstein,Gustavo Mostoslavsky,Jose Ordovas-Montanes,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Sabine Plancoulaine,Edmund Y. Tu,Yechiel Elkabetz,Saleh Al-Muhsen,Marc Tardieu,Thorsten M. Schlaeger,George Q. Daley,Laurent Abel,Laurent Abel,Jean-Laurent Casanova,Jean-Laurent Casanova,Lorenz Studer,Luigi D. Notarangelo,Luigi D. Notarangelo +29 more
TL;DR: Impaired TLR3- and UNC-93B-dependent IFN-α/β intrinsic immunity to HSV-1 in the CNS, in neurons and oligodendrocytes in particular, may underlie the pathogenesis of HSE in children with TLR 3-pathway deficiencies.
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Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency
Vanessa Sancho-Shimizu,Rebeca Pérez de Diego,Lazaro Lorenzo,Rabih Halwani,Abdullah A. Alangari,Elisabeth Israelsson,Sylvie Fabrega,Annabelle Cardon,Jérome Maluenda,Megumi Tatematsu,Farhad Mahvelati,Melina Herman,Michael J. Ciancanelli,Yiqi Guo,Zobaida Alsum,Nouf Alkhamis,Abdulkarim S. Al-Makadma,Ata Ghadiri,Soraya Boucherit,Sabine Plancoulaine,Capucine Picard,Flore Rozenberg,Marc Tardieu,Pierre Lebon,Emmanuelle Jouanguy,Nima Rezaei,Tsukasa Seya,Misako Matsumoto,Damien Chaussabel,Anne Puel,Shen-Ying Zhang,Laurent Abel,Saleh Al-Muhsen,Jean-Laurent Casanova +33 more
TL;DR: It is suggested that the TRIF-dependent TLR4 and DExD/H-box helicase pathways are largely redundant in host defense and the importance of TRIF for the TLR3-dependent production of antiviral IFNs in the CNS during primary infection with HSV-1 in childhood is demonstrated.
Journal ArticleDOI
Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity
Yiqi Guo,Yiqi Guo,Magali Audry,Michael J. Ciancanelli,Laia Alsina,Laia Alsina,Joana Azevedo,Melina Herman,Melina Herman,Esperanza Anguiano,Vanessa Sancho-Shimizu,Lazaro Lorenzo,Elodie Pauwels,Elodie Pauwels,Paul Bastard Philippe,Rebeca Pérez de Diego,Annabelle Cardon,Guillaume Vogt,Capucine Picard,Zafitsara Zo Andrianirina,Flore Rozenberg,Pierre Lebon,Sabine Plancoulaine,Sabine Plancoulaine,Marc Tardieu,Valérie Doireau,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Damien Chaussabel,Damien Chaussabel,Frederic Geissmann,Laurent Abel,Laurent Abel,Jean-Laurent Casanova,Shen-Ying Zhang,Shen-Ying Zhang +35 more
TL;DR: A new autosomal recessive form of completeTLR3 deficiency reveals that human TLR3 is nonredundant in immunity against herpes simplex virus 1 in the central nervous system (CNS) but redundant in host defense against viruses outside the CNS.