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Elena Denisenko

Researcher at Massey University

Publications -  21
Citations -  1526

Elena Denisenko is an academic researcher from Massey University. The author has contributed to research in topics: Enhancer & Transcriptional regulation. The author has an hindex of 9, co-authored 17 publications receiving 905 citations. Previous affiliations of Elena Denisenko include Harry Perkins Institute of Medical Research & University of Western Australia.

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An atlas of human long non-coding RNAs with accurate 5′ ends

TL;DR: This work integrates multiple transcript collections to generate a comprehensive atlas of 27,919 human lncRNA genes with high-confidence 5′ ends and expression profiles across 1,829 samples from the major human primary cell types and tissues, identifying 19,175 potentially functional lncRNAs in the human genome.
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Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows

TL;DR: Systematic comparison of recovered cell types and their transcriptional profiles across the workflows has highlighted protocol-specific biases and thus enables researchers starting single-cell experiments to make an informed choice.
Posted ContentDOI

Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows

TL;DR: This study compares performance of several workflows applied to adult mouse kidneys and highlights protocol-specific biases important for the experimental design and data interpretation of single-cell and single-nucleus RNA sequencing.
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Predicting cell-to-cell communication networks using NATMI

TL;DR: Analysis of the Tabula Muris (organism-wide) atlas confirms the previous prediction that autocrine signalling is a major feature of cell-to-cell communication networks, while also revealing that hundreds of ligands and their cognate receptors are co-expressed in individual cells suggesting a substantial potential for self-signalling.
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scMatch: a single-cell gene expression profile annotation tool using reference datasets.

TL;DR: It is found that scMatch can rapidly and robustly annotate single cells with comparable accuracy to another recent cell annotation tool (SingleR), but that it is quicker and can handle larger reference datasets.