E
Elias Castanas
Researcher at University of Crete
Publications - 211
Citations - 10660
Elias Castanas is an academic researcher from University of Crete. The author has contributed to research in topics: Receptor & Cancer. The author has an hindex of 45, co-authored 206 publications receiving 9367 citations. Previous affiliations of Elias Castanas include Pierre-and-Marie-Curie University & National and Kapodistrian University of Athens.
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Whole transcriptome analysis of the ERα synthetic fragment P295-T311 (ERα17p) identifies specific ERα-isoform (ERα, ERα36)-dependent and -independent actions in breast cancer cells.
George Notas,Maria-Eleni Kampa,Vasiliki Pelekanou,Maria Troullinaki,Yves Jacquot,Guy Leclercq,Elias Castanas +6 more
TL;DR: This is the first work reporting a detailed ERα36‐specific transcriptional signature and it is reported that ERα17p‐induced transcripts related to apoptosis and actin modifying effects of the peptide are independent from its estrogen receptor(s)‐related actions.
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Are opioid peptides co-localized with vasopressin or oxytocin in the neural lobe of the rat?
Jean J. Nordmann,Monique Cazalis,Govindan Dayanithi,Elias Castanas,Pierre Giraud,Jean-Jacques Legros,Francine Louis +6 more
TL;DR: The rates at which the amount of neurohypophysial hormone and opioid peptides decreased, and the changes in the ratios between the amounts can be explained by mechanisms other than co-localisation of the different peptides are cast some doubt.
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The estrogen receptor: two or more molecules, multiple variants, diverse localizations, signaling and functions. Are we undergoing a paradigm-shift as regards their significance in breast cancer?
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of the EMT technique in the field of medicine and its applications in the context of regenerative medicine.
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Nitric oxide and pro-inflammatory cytokines in acute hepatitis B.
M Koulentaki,George Notas,Efthimia Petinaki,Vassilis Valatas,Ioannis A. Mouzas,Elias Castanas,Elias A. Kouroumalis +6 more
TL;DR: High levels of nitric oxide and its regulatory pro-inflammatory cytokines were found in a group of patients with uncomplicated acute hepatitis B, and the exact role of NO in the disease pathogenesis and outcome needs to be studied further.
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Kappa 3: a novel subtype of the kappa opioid site in bovine adrenal medulla, highly selective for Met-enkephalin-Arg6-Phe7.
TL;DR: It is proposed that this residual etorphine-identified site might represent a novel subtype of the kappa opioid site named kappa 3, and Met-enkephalin-Arg 6 Phe 7 might be its endogenous ligand.