E
Elias Castanas
Researcher at University of Crete
Publications - 211
Citations - 10660
Elias Castanas is an academic researcher from University of Crete. The author has contributed to research in topics: Receptor & Cancer. The author has an hindex of 45, co-authored 206 publications receiving 9367 citations. Previous affiliations of Elias Castanas include Pierre-and-Marie-Curie University & National and Kapodistrian University of Athens.
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Journal ArticleDOI
Reassessment of opioid binding sites in the rat brain
TL;DR: The distribution of delta and kappa sites in the central nervous system was correlated with the distribution of proenkephalin-A derived peptides and precursors, suggesting that these peptides could be their endogenous ligands.
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First- and Second-Trimester Reference Intervals for Thyroid Hormones during Pregnancy in “Rhea” Mother-Child Cohort, Crete, Greece
Polyxeni Karakosta,Leda Chatzi,Emmanouil Bagkeris,Vasiliki Daraki,Dimitris Alegakis,Elias Castanas,Manolis Kogevinas,Marilena Kampa +7 more
TL;DR: These trimester-specific population-based reference ranges for thyroid hormones during pregnancy in an iodine-sufficient area of the Mediterranean, Crete, Greece are essential in everyday clinical practice for the correct interpretation of thyroid hormone values and accurate classification of thyroid disorders.
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Activin-A causes Hepatic stellate cell activation via the induction of TNFα and TGFβ in Kupffer cells.
Foteini Kiagiadaki,Marilena Kampa,A. Voumvouraki,Elias Castanas,Elias A. Kouroumalis,George Notas +5 more
TL;DR: Activin-A may induce fibrosis in NASH and alcoholic cirrhosis via activation of KCs to express pro-inflammatory molecules that promote HSC-dependent fibrogenesis and could be a target for future anti-fibrotic therapies.
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The estrogen receptor alpha-derived peptide ERα17p (P295-T311) exerts pro-apoptotic actions in breast cancer cells in vitro and in vivo, independently from their ERα status
Vasiliki Pelekanou,Vasiliki Pelekanou,Marilena Kampa,Marilena Kampa,Dominique Gallo,George Notas,Maria Troullinaki,Hugues Duvillier,Yves Jacquot,Efstathios N. Stathopoulos,Elias Castanas,Guy Leclercq +11 more
TL;DR: Evidence is provided that ERα17p induces apoptosis in ERα‐positive and ‐negative breast cancer cells by an ER α‐independent membrane mechanism, triggering major pro‐apoptotic signaling cascades and providing a novel insight to ER regulation of cell fate.
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Impact of religiosity/spirituality on biological and preclinical markers related to cardiovascular disease. Results from the SPILI III study
Dimitrios Anyfantakis,Emmanouil K. Symvoulakis,Demosthenes B. Panagiotakos,Dimitrios Tsetis,Elias Castanas,Sue Shea,Maria Venihaki,Christos Lionis +7 more
TL;DR: These findings may be associated with a possible favourable effect of religiosity/spirituality on several cardio-metabolic determinants, therefore deserving further attention by healthcare practitioners and researchers.