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Elisa Gibson
Researcher at Structural Genomics Consortium
Publications - 8
Citations - 175
Elisa Gibson is an academic researcher from Structural Genomics Consortium. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 3, co-authored 7 publications receiving 69 citations.
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Journal ArticleDOI
A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5
Fengling Li,Steven Kennedy,Taraneh Hajian,Elisa Gibson,Alma Seitova,Chao Xu,Cheryl H. Arrowsmith,Masoud Vedadi +7 more
TL;DR: Radioactivity-based assays for kinetic characterization of m6A-RNA modifications by METTL3-14 complex and ALKBH5 and provide optimal assay conditions suitable for screening for ligands in a 384-well format with Z′ factors of 0.78 and 0.77, respectively are reported.
Journal ArticleDOI
PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase
Levi L. Blazer,Evelyne Lima-Fernandes,Elisa Gibson,Mohammad S. Eram,Peter Loppnau,Cheryl H. Arrowsmith,Matthieu Schapira,Masoud Vedadi +7 more
TL;DR: It is reported that PRDM7 is an efficient methyltransferase that selectively catalyzes the trimethylation of H3 lysine 4 (H3K4) both in vitro and in cells.
Journal ArticleDOI
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
David Dilworth,Ronan P Hanley,Renato Ferreira de Freitas,Renato Ferreira de Freitas,Abdellah Allali-Hassani,Abdellah Allali-Hassani,Mengqi Zhou,Mengqi Zhou,Naimee Mehta,Matthew R. Marunde,Suzanne Ackloo,Raquel Arminda Carvalho Machado,Aliakbar Khalili Yazdi,Dominic D G Owens,Victoria Vu,David Y Nie,David Y Nie,Mona Alqazzaz,Edyta Marcon,Fengling Li,Irene Chau,Albina Bolotokova,Su Qin,Su Qin,Ming Lei,Ming Lei,Yanli Liu,Yanli Liu,Magdalena M. Szewczyk,Aiping Dong,Sina Kazemzadeh,Tigran M. Abramyan,Irina K. Popova,Nathan W. Hall,Matthew J. Meiners,Marcus A. Cheek,Elisa Gibson,Dmitri Kireev,Jack Greenblatt,Michael-Christopher Keogh,Jinrong Min,Jinrong Min,Peter Brown,Masoud Vedadi,Masoud Vedadi,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Dalia Barsyte-Lovejoy,Dalia Barsyte-Lovejoy,Lindsey I. James,Matthieu Schapira,Matthieu Schapira +51 more
TL;DR: In this article, a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2 was presented, called UNC6934, which antagonizes the P WWP1 interaction with nucleosomal H3K36me2.
Journal ArticleDOI
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
Chenxi Xu,Fanye Meng,Kwang-Su Park,Aaron J. Storey,Weida Gong,Yi-Hsuan Tsai,Elisa Gibson,Stephanie D. Byrum,Dongxu Li,Rick D. Edmondson,Samuel G. Mackintosh,Masoud Vedadi,Masoud Vedadi,Ling Cai,Alan J. Tackett,H. Ümit Kaniskan,Jian Jin,Gang Greg Wang +17 more
TL;DR: In this paper, a NSD3-targeting proteolysis targeting chimera (PROTAC) was proposed, which achieves effective and specific targeting of NSD and associated cMyc node in tumor cells.
Journal ArticleDOI
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
Renato Ferreira de Freitas,Yanli Liu,Magdalena M. Szewczyk,Naimee Mehta,Fengling Li,David McLeod,Carlos Zepeda-Velázquez,David Dilworth,Ronan P Hanley,Elisa Gibson,Peter Brown,Rima Al-awar,Lindsey I. James,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Dalia Barsyte-Lovejoy,Dalia Barsyte-Lovejoy,Jinrong Min,Jinrong Min,Masoud Vedadi,Masoud Vedadi,Matthieu Schapira,Matthieu Schapira,Abdellah Allali-Hassani +23 more
TL;DR: In this article, a small-molecule antagonist called 3f was proposed to block the protein-protein interaction between the N-terminal PWWP domain of NSD2 and H3K36me2.