E
Elisabeth Skogh
Researcher at Linköping University
Publications - 13
Citations - 1283
Elisabeth Skogh is an academic researcher from Linköping University. The author has contributed to research in topics: Kynurenic acid & Kynurenine. The author has an hindex of 11, co-authored 13 publications receiving 1172 citations.
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Journal ArticleDOI
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia.
TL;DR: CSF levels of kynurenic acid in schizophrenic patients were found to correlate with age, which is indicative of a contribution of kysine-site of the N-methyl D-aspartate-receptor in the pathogenesis of schizophrenia.
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Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
Klas R. Linderholm,Elisabeth Skogh,Sara K. Olsson,Marja-Liisa Dahl,Marja-Liisa Dahl,Maria Holtze,Göran Engberg,Martin Samuelsson,Sophie Erhardt +8 more
TL;DR: The results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.
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Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.
Lilly Schwieler,Markus K. Larsson,Elisabeth Skogh,Magdalena E. Kegel,Funda Orhan,Sally Abdelmoaty,Anja Finn,Maria Bhat,Martin Samuelsson,Kristina Lundberg,Marja-Liisa Dahl,Carl M. Sellgren,Ina Schuppe-Koistinen,Camilla I. Svensson,Sophie Erhardt,Göran Engberg +15 more
TL;DR: It is suggested that IL-6 induces the KYN pathway, leading to increased production of the N-methyl-D-aspartate receptor antagonist KYNA in patients with schizophrenia.
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Imbalanced Kynurenine Pathway in Schizophrenia
Magdalena E. Kegel,Maria Bhat,Elisabeth Skogh,Martin Samuelsson,Kristina Lundberg,Marja-Liisa Dahl,Carl M. Sellgren,Lilly Schwieler,Göran Engberg,Ina Schuppe-Koistinen,Sophie Erhardt +10 more
TL;DR: Support is offered for an over-activated and imbalanced kynurenine pathway, favoring the production of KYNA over QUIN in patients with schizophrenia, and the CSF QUIN/KYNA ratio was lower in patients than in controls.
Journal ArticleDOI
Therapeutic drug monitoring data on olanzapine and its N-demethyl metabolite in the naturalistic clinical setting
TL;DR: The present TDM-based follow-up suggests that the influence of gender, smoking habits, and certain drug interactions may need to be considered for optimal dosage of OLA.