Markus K. Larsson

TL;DR: It is suggested that IL-6 induces the KYN pathway, leading to increased production of the N-methyl-D-aspartate receptor antagonist KYNA in patients with schizophrenia.

TL;DR: Results demonstrate that the elimination of Kmo in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorders.

TL;DR: Enhanced sensitivity to D-amphetamine-induced increase in locomotor activity as well as mild impairments in prepulse inhibition and memory suggest that the kynurenine pathway can link early-life infection with the development of neuropsychiatric disturbances in adulthood.

TL;DR: The results show that a specific inhibition of KAT II is associated with a marked reduction in VTA DA firing activity, which appears to be specifically executed by NMDA-receptors and mediated indirectly via a GABA(B)-receptor-induced disinhibition of DA neurons.

TL;DR: It is found that an acute increase in the brain KYNA levels caused increased corner time and percent peripheral activity but did not change the d- methamphetamine-induced locomotor response, while subchronic elevation of KYNA produced an exaggerated d-amphetamine-induced hyperlocomotion.