K
Klas R. Linderholm
Researcher at Karolinska Institutet
Publications - 16
Citations - 1585
Klas R. Linderholm is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Kynurenic acid & Ventral tegmental area. The author has an hindex of 13, co-authored 16 publications receiving 1435 citations.
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Journal ArticleDOI
Connecting inflammation with glutamate agonism in suicidality
Sophie Erhardt,Chai K. Lim,Klas R. Linderholm,Shorena Janelidze,Daniel Lindqvist,Martin Samuelsson,Kristina Lundberg,Teodor T. Postolache,Lil Träskman-Bendz,Gilles J. Guillemin,Gilles J. Guillemin,Lena Brundin,Lena Brundin +12 more
TL;DR: Clinical evidence of increased QUIN in the CSF of suicide attempters is presented and the correlation between QUIN and the Suicide Intent Scale indicates that changes in glutamatergic neurotransmission could be specifically linked to suicidality.
Journal ArticleDOI
Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
Klas R. Linderholm,Elisabeth Skogh,Sara K. Olsson,Marja-Liisa Dahl,Marja-Liisa Dahl,Maria Holtze,Göran Engberg,Martin Samuelsson,Sophie Erhardt +8 more
TL;DR: The results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.
Journal ArticleDOI
A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality.
Cecilie Bay-Richter,Klas R. Linderholm,Chai K. Lim,Martin Samuelsson,Lil Träskman-Bendz,Gilles J. Guillemin,Sophie Erhardt,Lena Brundin +7 more
TL;DR: It is suggested that patients with a dysregulated kynurenine pathway are vulnerable to develop depressive symptoms upon inflammatory conditions, as a result the excess production of the NMDA-receptor agonist quinolinic acid.
Journal ArticleDOI
Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia.
L.K. Nilsson,Klas R. Linderholm,Göran Engberg,Linda Paulson,Kaj Blennow,Leif Lindström,Conny Nordin,A Karanti,P Persson,Sophie Erhardt +9 more
TL;DR: Results confirm that CSF KYNA concentration is elevated in patients with schizophrenia and are consistent with the hypothesis that KYNA contributes to the pathophysiology of the disease.
Journal ArticleDOI
The kynurenic acid hypothesis of schizophrenia.
TL;DR: The results suggest that kynurenic acid contributes to the pathogenesis of schizophrenia and link the dopamine hypothesis of schizophrenia together with the idea of a deficiency in glutamatergic function in this disease.