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Eliza Joodmardi
Researcher at Ludwig Institute for Cancer Research
Publications - 14
Citations - 1584
Eliza Joodmardi is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Dopaminergic & Neuron. The author has an hindex of 14, co-authored 14 publications receiving 1341 citations. Previous affiliations of Eliza Joodmardi include Max Planck Society.
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Journal ArticleDOI
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
Banafsheh Kadkhodaei,Takehito Ito,Eliza Joodmardi,Bengt Mattsson,Claude Rouillard,Manolo Carta,Shin-ichi Muramatsu,Chiho Sumi-Ichinose,Takahide Nomura,Daniel Metzger,Pierre Chambon,Eva Lindqvist,Nils-Göran Larsson,Lars Olson,Anders Björklund,Hiroshi Ichinose,Thomas Perlmann +16 more
TL;DR: The results show that developmental pathways play key roles for the maintenance of terminally differentiated neurons and suggest that disrupted function of Nurr1 and other developmental transcription factors may contribute to neurodegenerative disease.
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Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development
Katarina Tiklova,Åsa K. Björklund,Laura Lahti,Alessandro Fiorenzano,Sara Nolbrant,Linda Gillberg,Nikolaos Volakakis,Chika Yokota,Markus M. Hilscher,Thomas Hauling,Fredrik Holmström,Eliza Joodmardi,Mats Nilsson,Malin Parmar,Thomas Perlmann,Thomas Perlmann +15 more
TL;DR: Single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) is used to identify and characterize seven neuron subgroups divided in two major branches of developing PitX3-expressing neurons.
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p57(Kip2) cooperates with Nurr1 in developing dopamine cells.
Bertrand Joseph,Åsa Wallén-Mackenzie,Gérard Benoit,Takashi Murata,Eliza Joodmardi,Sam Okret,Thomas Perlmann +6 more
TL;DR: Evidence indicates that p57Kip2 functions by a direct protein–protein interaction with Nurr1, an orphan nuclear receptor that is essential for dopamine neuron development, and reveals a mechanism whereby p57 Kip2 influences postmitotic differentiation of dopamine neurons.
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Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
Banafsheh Kadkhodaei,Alexandra Alvarsson,Nicoletta Schintu,Daniel Ramsköld,Nikolaos Volakakis,Eliza Joodmardi,Takashi Yoshitake,Jan Kehr,Mickael Decressac,Anders Björklund,Rickard Sandberg,Rickard Sandberg,Per Svenningsson,Thomas Perlmann,Thomas Perlmann +14 more
TL;DR: It is shown that Nurr1 ablation results in a progressive pathology associated with reduced striatal DA, impaired motor behaviors, and dystrophic axons and dendrites, and that Nur r 1 ablation in mice recapitulates early features of Parkinson's disease.
Journal ArticleDOI
NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.
Nikolaos Volakakis,Banafsheh Kadkhodaei,Eliza Joodmardi,Karin Wallis,Lia Panman,Jessica M. Silvaggi,Bruce M. Spiegelman,Thomas Perlmann +7 more
TL;DR: It is demonstrated that NR4A and the transcriptional coactivator PGC-1α independently regulate distinct CREB-dependent neuroprotective gene programs and are identified as essential mediators of neuroprotection after exposure to neuropathological stress.