Elizabeth M. Bradshaw

TL;DR: It is demonstrated that IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function, and a role of IL- 9 as a regulator of pathogenic versus protective mechanisms of immune responses is highlighted.

TL;DR: The transcriptsome of aged human cortical microglia are described, and age-related gene expression as related to neurodegeneration is shown, confirming the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.

TL;DR: The construction and validation of a molecular network of the aging human frontal cortex is reported, constructed and validated from RNA sequence data from 478 individuals and identified genes that affect cognitive decline or neuropathology in Alzheimer's disease.

TL;DR: Serial, time-dependent, single-cell analysis of primary human T cells is used to resolve the temporal dynamics of cytokine secretion from individual cells after activation ex vivo and shows that multifunctional, Th1-skewed cytokine responses are initiated asynchronously, but the ensuing dynamic trajectories of these responses evolve programmatically in a sequential manner.

TL;DR: The population structure of live microglia purified from human cerebral cortex samples obtained at autopsy and during neurosurgical procedures is investigated, and it is found that some subsets are enriched for disease-related genes and RNA signatures.