P
Paul D. Piehowski
Researcher at Pacific Northwest National Laboratory
Publications - 95
Citations - 4663
Paul D. Piehowski is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Proteomics & Proteome. The author has an hindex of 28, co-authored 79 publications receiving 2741 citations. Previous affiliations of Paul D. Piehowski include Environmental Molecular Sciences Laboratory & Pennsylvania State University.
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Journal ArticleDOI
A transcriptomic atlas of aged human microglia
Marta Olah,Marta Olah,Ellis Patrick,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Jishu Xu,Charles C. White,Katie J. Ryan,Paul D. Piehowski,Alifiya Kapasi,Parham Nejad,Maria Cimpean,Sarah M. Connor,Sarah M. Connor,Christina J. Yung,Michael Frangieh,Allison McHenry,Wassim Elyaman,Wassim Elyaman,Vlad Petyuk,Julie A. Schneider,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw +25 more
TL;DR: The transcriptsome of aged human cortical microglia are described, and age-related gene expression as related to neurodegeneration is shown, confirming the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.
Journal ArticleDOI
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.
David J. Clark,Saravana M. Dhanasekaran,Francesca Petralia,Jianbo Pan,Xiaoyu Song,Yingwei Hu,Felipe da Veiga Leprevost,Boris Reva,Tung-Shing M. Lih,Hui Yin Chang,Weiping Ma,Chen Huang,Christopher J. Ricketts,Lijun Chen,Azra Krek,Yize Li,Dmitry Rykunov,Qing Kay Li,Lin Chen,Umut Ozbek,Suhas Vasaikar,Yige Wu,Seungyeul Yoo,Shrabanti Chowdhury,Matthew A. Wyczalkowski,Jiayi Ji,Michael Schnaubelt,Andy T. Kong,Sunantha Sethuraman,Dmitry M. Avtonomov,Minghui Ao,Antonio Colaprico,Song Cao,Kyung-Cho Cho,Selim Kalayci,Shiyong Ma,Wenke Liu,Kelly V. Ruggles,Anna Calinawan,Zeynep H. Gümüş,Daniel J. Geiszler,Emily Kawaler,Guo Ci Teo,Bo Wen,Yuping Zhang,Sarah Keegan,Kai Li,Feng Chen,Nathan Edwards,Phillip M. Pierorazio,Xi Steven Chen,Christian P. Pavlovich,A. Ari Hakimi,Gabriel Bromiński,James J. Hsieh,Andrzej Antczak,Tatiana Omelchenko,Jan Lubinski,Maciej Wiznerowicz,Maciej Wiznerowicz,W. Marston Linehan,Christopher R. Kinsinger,Mathangi Thiagarajan,Emily S. Boja,Mehdi Mesri,Tara Hiltke,Ana I. Robles,Henry Rodriguez,Jiang Qian,David Fenyö,Bing Zhang,Li Ding,Eric E. Schadt,Arul M. Chinnaiyan,Zhen Zhang,Gilbert S. Omenn,Marcin Cieslik,Daniel W. Chan,Alexey I. Nesvizhskii,Pei Wang,Hui Zhang,Abdul Samad Hashimi,Alexander R. Pico,Alla Y. Karpova,Alyssa Charamut,Amanda G. Paulovich,Amy M. Perou,Anna Malovannaya,Annette Marrero-Oliveras,Anupriya Agarwal,Barbara Hindenach,Barbara Pruetz,Beom-Jun Kim,Brian J. Druker,Chelsea J. Newton,Chet Birger,Corbin D. Jones,Cristina E. Tognon,D. R. Mani,Dana R. Valley,Daniel C. Rohrer,Daniel C. Zhou,Darlene Tansil,David Chesla,David I. Heiman,David C. Wheeler,Donghui Tan,Doug W. Chan,Emek Demir,Ewa P. Malc,Francesmary Modugno,Gaddy Getz,Galen Hostetter,George D. Wilson,Gerald W. Hart,Heng Zhu,Hongwei Liu,Houston Culpepper,Hua Sun,Hua Zhou,Jacob J. Day,James Suh,Jasmine Huang,Jason E. McDermott,Jeffrey R. Whiteaker,Jeffrey W. Tyner,Jennifer M. Eschbacher,Jin Chen,John McGee,Jun Zhu,Karen A. Ketchum,Karin D. Rodland,Karl R. Clauser,Karna Robinson,Karsten Krug,Katherine A. Hoadley,Ki Sung Um,Kim Elburn,Kimberly R. Holloway,Liang-Bo Wang,Lili Blumenberg,Linda Hannick,Liqun Qi,Lori J. Sokoll,MacIntosh Cornwell,Marc M. Loriaux,Marcin J. Domagalski,Marina A. Gritsenko,Matthew L. Anderson,Matthew E. Monroe,Matthew J. Ellis,Maureen Dyer,Meenakshi Anurag,Meghan C. Burke,Melissa Borucki,Michael A. Gillette,Michael J. Birrer,Michael T. Lewis,Michael Ittmann,Michael Smith,Michael Vernon,Michelle Chaikin,Milan G. Chheda,Munziba Khan,Nancy Roche,Nathan Edwards,Negin Vatanian,Nicole Tignor,Noam D. Beckmann,Pamela Grady,Patricia Castro,Paul D. Piehowski,Peter B. McGarvey,Piotr A. Mieczkowski,Pushpa Hariharan,Qingsong Gao,Rajiv Dhir,Ramani B. Kothadia,Ratna R. Thangudu,Rebecca I. Montgomery,Reyka G Jayasinghe,Richard D. Smith,Robert Edwards,Robert Zelt,Ross Bremner,Ruiyang Liu,Runyu Hong,Sailaja Mareedu,Samuel H. Payne,Sandra Cottingham,Sanford P. Markey,Scott D. Jewell,Shalin Patel,Shankha Satpathy,Shannon Richey,Sherri R. Davies,Shuang Cai,Simina M. Boca,Snehal Patil,Sohini Sengupta,Sonya Carter,Stacey Gabriel,Stefani N. Thomas,Stephanie De Young,Stephen E. Stein,Steven A. Carr,Steven M. Foltz,Sue Hilsenbeck,Tanya Krubit,Tao Liu,Tara Skelly,Thomas F. Westbrook,Uma Borate,Uma Velvulou,Vladislav A. Petyuk,William Bocik,Xi Chen,Yan Shi,Yifat Geffen,Yihao Lu,Ying Wang,Yosef E. Maruvka,Zhi Li,Zhiao Shi,Zhidong Tu +224 more
TL;DR: A large-scale proteogenomic analysis of ccRCC is reported to discern the functional impact of genomic alterations and provides evidence for rational treatment selection stemming fromccRCC pathobiology.
Journal ArticleDOI
Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.
Ying Zhu,Paul D. Piehowski,Rui Zhao,Jing Chen,Yufeng Shen,Ronald J. Moore,Anil K. Shukla,Vladislav A. Petyuk,Martha Campbell-Thompson,Clayton E. Mathews,Richard D. Smith,Wei-Jun Qian,Ryan T. Kelly +12 more
TL;DR: A robotically controlled chip-based nanodroplet processing platform is established and its ability to profile the proteome from 10–100 mammalian cells is demonstrated, illustrating the application of nanoPOTS for spatially resolved proteome measurements from clinical tissues.
Journal ArticleDOI
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Michael Snyder,Shin Lin,Amanda Posgai,Mark A. Atkinson,Aviv Regev,Jennifer Rood,Orit Rozenblatt-Rosen,Leslie Gaffney,Anna Hupalowska,Rahul Satija,Nils Gehlenborg,Jay Shendure,Julia Laskin,Pehr B. Harbury,Nicholas A. Nystrom,Jonathan C. Silverstein,Ziv Bar-Joseph,Kun Zhang,Katy Börner,Yiing Lin,Richard Conroy,Dena Procaccini,Ananda L. Roy,Ajay Pillai,Marishka Brown,Zorina S. Galis,Caltech-UW Tmc,Long Cai,Cole Trapnell,Dana Jackson,Stanford-WashU Tmc,Garry P. Nolan,William J. Greenleaf,Sylvia K. Plevritis,Sara Ahadi,Stephanie A. Nevins,Hayan Lee,Christian Martijn Schuerch,Sarah Black,Vishal G. Venkataraaman,Ed Esplin,Aaron M. Horning,Amir Bahmani,Ucsd Tmc,Xin bSun,Sanjay Jain,James S. Hagood,Gloria S. Pryhuber,Peter V. Kharchenko,Bernd bBodenmiller,Todd M. Brusko,Michael J. Clare-Salzler,Harry S. Nick,Kevin J. Otto,Clive hWasserfall,Marda Jorgensen,Maigan A. Brusko,Sergio Maffioletti,Richard M. Caprioli,Jeffrey M. Spraggins,Danielle cGutierrez,Nathan Heath Patterson,Elizabeth K. Neumann,Raymond C. Harris,Mark P. deCaestecker,Agnes B. Fogo,Raf Van de Plas,Ken S. Lau,Guo-Cheng Yuan,Qian Zhu,Ruben Dries,Harvard Ttd,Peng Yin,Sinem K. Saka,Jocelyn Y. Kishi,Yu Wang,Isabel Goldaracena,Purdue Ttd,DongHye Ye,Kristin E. Burnum-Johnson,Paul D. Piehowski,Charles Ansong,Ying Zhu,Stanford Ttd,Tushar bDesai,Jay Mulye,Peter Chou,Monica Nagendran,Visualization HuBMAP Integration,Sarah A. Teichmann,Benedict aten,Robert F. dMurphy,Jian Ma,Vladimir Yu. Kiselev,Carl Kingsford,Allyson Ricarte,Maria Keays,Sushma A. Akoju,Matthew Ruffalo,Margaret Vella,Chuck McCallum,Leonard E. Cross,Samuel H. Friedman,Randy Heiland,Bruce Herr,Paul Macklin,Ellen M. Quardokus,Lisel Record,James P. Sluka,Griffin M. Weber,Engagement Component,Philip D. Blood,Alexander J. Ropelewski,William E. Shirey,Robin M. Scibek,Paula M. Mabee,W. Christopher Lenhardt,Kimberly Robasky,Stavros Michailidis,John C. Marioni,Andrew Butler,Tim Stuart,Eyal Fisher,Shila Ghazanfar,Gökcen Eraslan,Tommaso Biancalani,Eeshit Dhaval Vaishnav,Ananda L. Roy,Zorina S. Galis,Pothur Srinivas,Aaron Pawlyk,Salvatore Sechi,Elizabeth L. Wilder,James E. Anderson +133 more
TL;DR: The NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping.
Journal ArticleDOI
Proteogenomic Characterization of Endometrial Carcinoma.
Yongchao Dou,Emily Kawaler,Daniel Cui Zhou,Marina A. Gritsenko,Chen Huang,Lili Blumenberg,Alla Karpova,Vladislav A. Petyuk,Sara R. Savage,Shankha Satpathy,Wenke Liu,Yige Wu,Chia-Feng Tsai,Bo Wen,Zhi Li,Song Cao,Jamie Moon,Zhiao Shi,MacIntosh Cornwell,Matthew A. Wyczalkowski,Rosalie K. Chu,Suhas Vasaikar,Hua Zhou,Qingsong Gao,Ronald J. Moore,Kai Li,Sunantha Sethuraman,Matthew E. Monroe,Rui Zhao,David I. Heiman,Karsten Krug,Karl R. Clauser,Ramani Kothadia,Yosef E. Maruvka,Alexander R. Pico,Amanda E. Oliphant,Emily L. Hoskins,Samuel L. Pugh,Sean J.I. Beecroft,David W Adams,Jonathan C. Jarman,Andy T. Kong,Hui Yin Chang,Boris Reva,Yuxing Liao,Dmitry Rykunov,Antonio Colaprico,Xi Steven Chen,Andrzej Czekański,Marcin Jędryka,Rafal Matkowski,Maciej Wiznerowicz,Maciej Wiznerowicz,Tara Hiltke,Emily S. Boja,Christopher R. Kinsinger,Mehdi Mesri,Ana I. Robles,Henry Rodriguez,David G. Mutch,Katherine Fuh,Matthew J. Ellis,Deborah DeLair,Mathangi Thiagarajan,D. R. Mani,Gad Getz,Michael S. Noble,Alexey I. Nesvizhskii,Pei Wang,Matthew L. Anderson,Douglas A. Levine,Richard D. Smith,Samuel H. Payne,Kelly V. Ruggles,Karin D. Rodland,Karin D. Rodland,Li Ding,Bing Zhang,Tao Liu,David Fenyö,Anupriya Agarwal,Meenakshi Anurag,Dmitry M. Avtonomov,Chet Birger,Michael J. Birrer,Simina M. Boca,William Bocik,Uma Borate,Melissa Borucki,Meghan C. Burke,Shuang Cai,Anna Calinawan,Steven A. Carr,Sonya Carter,Patricia Castro,Sandra Cerda,Michelle Chaikin,Daniel W. Chan,Doug W. Chan,Alyssa Charamut,Feng Chen,Jin Chen,Lijun Chen,Lin Chen,David Chesla,Milan G. Chheda,Arul M. Chinnaiyan,Shrabanti Chowdhury,Marcin Cieslik,David J. Clark,Sandra Cottingham,Houston Culpepper,Jacob J. Day,Stephanie De Young,Emek Demir,Saravana M. Dhanasekaran,Rajiv Dhir,Marcin J. Domagalski,Peter Dottino,Brian J. Druker,Elizabeth R. Duffy,Maureen Dyer,Nathan Edwards,Robert Edwards,Kim Elburn,Jayson B. Field,Alicia Francis,Stacey Gabriel,Yifat Geffen,Daniel J. Geiszler,Michael A. Gillette,Andrew K. Godwin,Pamela Grady,Linda Hannick,Pushpa Hariharan,Sue Hilsenbeck,Barbara Hindenach,Katherine A. Hoadley,Runyu Hong,Galen Hostetter,James J. Hsieh,Yingwei Hu,Michael Ittmann,Eric J. Jaehnig,Scott D. Jewell,Jiayi Ji,Corbin D. Jones,Renee Karabon,Karen A. Ketchum,Munziba Khan,Beom-Jun Kim,Azra Krek,Tanya Krubit,Chandan Kumar-Sinha,Felipe D. Leprevost,Michael T. Lewis,Qing Kay Li,Yize Li,Hongwei Liu,Jan Lubinski,Weiping Ma,Rashna Madan,Ewa P. Malc,Anna Malovannaya,Sailaja Mareedu,Sanford P. Markey,Annette Marrero-Oliveras,John A. Martignetti,Jason E. McDermott,Peter B. McGarvey,John McGee,Piotr A. Mieczkowski,Francesmary Modugno,Rebecca I. Montgomery,Chelsea J. Newton,Gilbert S. Omenn,Amanda G. Paulovich,Amy M. Perou,Francesca Petralia,Paul D. Piehowski,Larisa Polonskaya,Liqun Qi,Shannon Richey,Karna Robinson,Nancy Roche,Daniel C. Rohrer,Eric E. Schadt,Michael Schnaubelt,Yan Shi,Tara Skelly,Lori J. Sokoll,Xiaoyu Song,Stephen E. Stein,James Suh,Donghui Tan,Darlene Tansil,Guo Ci Teo,Ratna R. Thangudu,Cristina E. Tognon,Elie Traer,Jeffrey W. Tyner,Ki Sung Um,Dana R. Valley,Negin Vatanian,Pankaj Vats,Uma Velvulou,Michael Vernon,Liang-Bo Wang,Ying Wang,Alex Webster,Thomas F. Westbrook,David C. Wheeler,Jeffrey R. Whiteaker,George D. Wilson,Yuriy Zakhartsev,Robert Zelt,Hui Zhang,Yuping Zhang,Zhen Zhang,Grace Zhao +219 more
TL;DR: A comprehensive proteogenomic characterization of endometrial carcinomas revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways.