E
Estelle Bettelli
Researcher at Harvard University
Publications - 15
Citations - 13608
Estelle Bettelli is an academic researcher from Harvard University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Myelin oligodendrocyte glycoprotein. The author has an hindex of 9, co-authored 15 publications receiving 12669 citations. Previous affiliations of Estelle Bettelli include Brigham and Women's Hospital.
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Journal ArticleDOI
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
Journal ArticleDOI
IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
Journal ArticleDOI
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
Thomas Korn,Jayagopala Reddy,Wenda Gao,Estelle Bettelli,Amit Awasthi,Troels R. Petersen,B Thomas Bäckström,Raymond A. Sobel,Raymond A. Sobel,Kai W. Wucherpfennig,Terry B. Strom,Mohamed Oukka,Vijay K. Kuchroo +12 more
TL;DR: The data suggest that in order for CD4+Foxp3+ T-reg to effectively control autoimmune reactions in the target organ, it may also be necessary to control tissue inflammation.
Journal ArticleDOI
Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis
Estelle Bettelli,Brandon M. Sullivan,Susanne J. Szabo,Raymond A. Sobel,Raymond A. Sobel,Laurie H. Glimcher,Vijay K. Kuchroo +6 more
TL;DR: Enhanced EAE in STAT1−/− mice was associated with continued generation of IFN-γ–producing Th1 cells and up-regulation of selective chemokines responsible for the increased recruitment of macrophages and neutrophils in the central nervous system.
Journal ArticleDOI
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells
Wassim Elyaman,Elizabeth M. Bradshaw,Catherine Uyttenhove,Valérie Dardalhon,Amit Awasthi,Jaime Imitola,Estelle Bettelli,Mohamed Oukka,Jacques Van Snick,Jean-Christophe Renauld,Vijay K. Kuchroo,Samia J. Khoury +11 more
TL;DR: It is demonstrated that IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function, and a role of IL- 9 as a regulator of pathogenic versus protective mechanisms of immune responses is highlighted.