E
Elizabeth M. Bradshaw
Researcher at Columbia University Medical Center
Publications - 32
Citations - 2727
Elizabeth M. Bradshaw is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Microglia & Cognitive decline. The author has an hindex of 18, co-authored 26 publications receiving 1965 citations. Previous affiliations of Elizabeth M. Bradshaw include Brigham and Women's Hospital & Columbia University.
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Journal ArticleDOI
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells
Wassim Elyaman,Elizabeth M. Bradshaw,Catherine Uyttenhove,Valérie Dardalhon,Amit Awasthi,Jaime Imitola,Estelle Bettelli,Mohamed Oukka,Jacques Van Snick,Jean-Christophe Renauld,Vijay K. Kuchroo,Samia J. Khoury +11 more
TL;DR: It is demonstrated that IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function, and a role of IL- 9 as a regulator of pathogenic versus protective mechanisms of immune responses is highlighted.
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A transcriptomic atlas of aged human microglia
Marta Olah,Marta Olah,Ellis Patrick,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Jishu Xu,Charles C. White,Katie J. Ryan,Paul D. Piehowski,Alifiya Kapasi,Parham Nejad,Maria Cimpean,Sarah M. Connor,Sarah M. Connor,Christina J. Yung,Michael Frangieh,Allison McHenry,Wassim Elyaman,Wassim Elyaman,Vlad Petyuk,Julie A. Schneider,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw +25 more
TL;DR: The transcriptsome of aged human cortical microglia are described, and age-related gene expression as related to neurodegeneration is shown, confirming the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.
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A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.
Sara Mostafavi,Sara Mostafavi,Chris Gaiteri,Sarah E. Sullivan,Charles C. White,Shinya Tasaki,Jishu Xu,Mariko Taga,Mariko Taga,Hans-Ulrich Klein,Hans-Ulrich Klein,Ellis Patrick,Vitalina Komashko,Cristin McCabe,Robert V. Smith,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw,David E. Root,Aviv Regev,Lei Yu,Lori B. Chibnik,Lori B. Chibnik,Julie A. Schneider,Tracy L. Young-Pearse,Tracy L. Young-Pearse,David A. Bennett,Philip L. De Jager,Philip L. De Jager +27 more
TL;DR: The construction and validation of a molecular network of the aging human frontal cortex is reported, constructed and validated from RNA sequence data from 478 individuals and identified genes that affect cognitive decline or neuropathology in Alzheimer's disease.
Journal ArticleDOI
Polyfunctional responses by human T cells result from sequential release of cytokines
Qing Han,Neda Bagheri,Elizabeth M. Bradshaw,David A. Hafler,David A. Hafler,Douglas A. Lauffenburger,Douglas A. Lauffenburger,J. Christopher Love +7 more
TL;DR: Serial, time-dependent, single-cell analysis of primary human T cells is used to resolve the temporal dynamics of cytokine secretion from individual cells after activation ex vivo and shows that multifunctional, Th1-skewed cytokine responses are initiated asynchronously, but the ensuing dynamic trajectories of these responses evolve programmatically in a sequential manner.
Journal ArticleDOI
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
Marta Olah,Vilas Menon,Naomi Habib,Naomi Habib,Mariko Taga,Yiyi Ma,Christina J. Yung,Maria Cimpean,Anthony Khairallah,Guillermo Coronas-Samano,Roman Sankowski,Dominic Grün,Alexandra Kroshilina,Danielle Dionne,Rani A. Sarkis,Garth Rees Cosgrove,Jeffrey Helgager,Jeffrey A. Golden,Page B. Pennell,Marco Prinz,Jean Paul Vonsattel,Andrew F. Teich,Julie A. Schneider,David A. Bennett,Aviv Regev,Wassim Elyaman,Wassim Elyaman,Elizabeth M. Bradshaw,Elizabeth M. Bradshaw,Philip L. De Jager +29 more
TL;DR: The population structure of live microglia purified from human cerebral cortex samples obtained at autopsy and during neurosurgical procedures is investigated, and it is found that some subsets are enriched for disease-related genes and RNA signatures.