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Elizabeth W. Scadden
Researcher at Harvard University
Publications - 8
Citations - 273
Elizabeth W. Scadden is an academic researcher from Harvard University. The author has contributed to research in topics: Bone marrow & Haematopoiesis. The author has an hindex of 4, co-authored 5 publications receiving 96 citations.
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Journal ArticleDOI
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.
Nicolas Severe,Nezihi Murat Karabacak,Nezihi Murat Karabacak,Karin Gustafsson,Ninib Baryawno,Gabriel Courties,Youmna Kfoury,Konstantinos D. Kokkaliaris,Catherine Rhee,Dongjun Lee,Elizabeth W. Scadden,Juan Esteban Garcia-Robledo,Thomas Brouse,Matthias Nahrendorf,Mehmet Toner,Mehmet Toner,David T. Scadden +16 more
TL;DR: This protein-based expression mapping reveals distinct sets of stromal cells in the bone marrow and how they change in clinically relevant stress settings to contribute to early stages of hematopoietic regeneration.
Journal ArticleDOI
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.
Youmna Kfoury,Ninib Baryawno,Nicolas Severe,Shenglin Mei,Karin Gustafsson,Taghreed Hirz,Thomas Brouse,Elizabeth W. Scadden,Anna A. Igolkina,Konstantinos D. Kokkaliaris,Bryan D. Choi,Nikolas Barkas,Mark A. Randolph,John H. Shin,Philip J. Saylor,David T. Scadden,David B. Sykes,Peter V. Kharchenko +17 more
TL;DR: In this article, the authors define distinct features of the bone marrow microenvironment by analyzing single cells from bone metastatic prostate tumors, involved BM, uninvolved BM, and BM from cancer-free, orthopedic patients, and healthy individuals.
Posted ContentDOI
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment
Ninib Baryawno,Youmna Kfoury,Nicolas Severe,Shenglin Mei,Karin Gustafsson,Taghreed Hirz,Thomas Brouse,Elizabeth W. Scadden,Anna A. Igolkina,Bryan D. Choi,Nikolas Barkas,John H. Shin,Philip J. Saylor,David T. Scadden,David B. Sykes,Peter V. Kharchenko +15 more
TL;DR: Comparative high resolution analysis of prostate cancer bone metastasis shows a targeted approach for relieving local immunosuppression for therapeutic effect.
Journal ArticleDOI
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Rushdia Z. Yusuf,Borja Saez,Azeem Sharda,Nick van Gastel,Vionnie W.C. Yu,Ninib Baryawno,Elizabeth W. Scadden,Sanket S. Acharya,Shrikanta Chattophadhyay,Cherrie Huang,Vasanthi Viswanathan,Dana S'aulis,Julien Cobert,David B. Sykes,Mark A. Keibler,Sudeshna Das,John N. Hutchinson,Michael Churchill,Siddhartha Mukherjee,Dongjun Lee,Francois Mercier,John G. Doench,Lars Bullinger,David J. Logan,Stuart L. Schreiber,Gregory Stephanopoulos,William B. Rizzo,David T. Scadden +27 more
TL;DR: Inhibiting Aldh3a2 provides a therapeutic opportunity and a unique synthetic lethality to exploit the distinctive metabolic state of malignant cells in acute myeloid leukemia.
Journal ArticleDOI
Reduced ER–mitochondria connectivity promotes neuroblastoma multidrug resistance
Jorida Coku,David Booth,Jan Skoda,Madison C. Pedrotty,Jennifer Vogel,Kang-Da Liu,Annette Vu,Erica L. Carpenter,J. Ye,Michelle Chen,P. Dunbar,Elizabeth W. Scadden,Taekyung D Yun,Eiko Nakamaru-Ogiso,Estela Area-Gomez,Yi-min Li,Kelly C. Goldsmith,C. Patrick Reynolds,György Hajnóczky,Michael D. Hogarty +19 more
TL;DR: Electron microscopy identifies ER–mitochondria‐associated membranes as physiologic regulators of apoptosis via ceramide transfer and uncover a previously unrecognized mechanism for cancer multidrug resistance.