C
Cherrie Huang
Researcher at Broad Institute
Publications - 7
Citations - 1110
Cherrie Huang is an academic researcher from Broad Institute. The author has contributed to research in topics: Stromal cell & Bone marrow. The author has an hindex of 4, co-authored 7 publications receiving 620 citations. Previous affiliations of Cherrie Huang include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Vasanthi S. Viswanathan,Matthew J. Ryan,Harshil Dhruv,Shubhroz Gill,Ossia M. Eichhoff,Brinton Seashore-Ludlow,Samuel D. Kaffenberger,John K. Eaton,Kenichi Shimada,Andrew J. Aguirre,Andrew J. Aguirre,Srinivas R. Viswanathan,Srinivas R. Viswanathan,Shrikanta Chattopadhyay,Pablo Tamayo,Pablo Tamayo,Wan Seok Yang,Matthew G. Rees,Sixun Chen,Zarko V. Boskovic,Sarah Javaid,Cherrie Huang,Xiaoyun Wu,Yuen-Yi Tseng,Elisabeth Roider,Dong Gao,James M. Cleary,Brian M. Wolpin,Jill P. Mesirov,Jill P. Mesirov,Daniel A. Haber,Daniel A. Haber,Jeffrey A. Engelman,Jesse S. Boehm,Joanne Kotz,Cindy S. Hon,Yu Chen,William C. Hahn,William C. Hahn,Mitchell P. Levesque,John G. Doench,Michael E. Berens,Alykhan F. Shamji,Paul A. Clemons,Brent R. Stockwell,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber +47 more
TL;DR: Vulnerability to ferroptic cell death induced by inhibition of a lipid peroxidase pathway as a feature of therapy-resistant cancer cells across diverse mesenchymal cell-state contexts is identified.
Journal ArticleDOI
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Rushdia Z. Yusuf,Borja Saez,Azeem Sharda,Nick van Gastel,Vionnie W.C. Yu,Ninib Baryawno,Elizabeth W. Scadden,Sanket S. Acharya,Shrikanta Chattophadhyay,Cherrie Huang,Vasanthi Viswanathan,Dana S'aulis,Julien Cobert,David B. Sykes,Mark A. Keibler,Sudeshna Das,John N. Hutchinson,Michael Churchill,Siddhartha Mukherjee,Dongjun Lee,Francois Mercier,John G. Doench,Lars Bullinger,David J. Logan,Stuart L. Schreiber,Gregory Stephanopoulos,William B. Rizzo,David T. Scadden +27 more
TL;DR: Inhibiting Aldh3a2 provides a therapeutic opportunity and a unique synthetic lethality to exploit the distinctive metabolic state of malignant cells in acute myeloid leukemia.
Journal ArticleDOI
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors
Shrikanta Chattopadhyay,Shrikanta Chattopadhyay,Alison L. Stewart,Siddhartha Mukherjee,Cherrie Huang,Cherrie Huang,Kimberly A. Hartwell,Peter Miller,Peter Miller,Radhika Subramanian,Leigh C. Carmody,Rushdia Z. Yusuf,David B. Sykes,Joshiawa Paulk,Joshiawa Paulk,Amedeo Vetere,Sonia Vallet,Loredana Santo,Diana Cirstea,Teru Hideshima,Vlado Dančík,Max M. Majireck,Max M. Majireck,Mahmud M. Hussain,Mahmud M. Hussain,Mahmud M. Hussain,Shambhavi Singh,Shambhavi Singh,Ryan Quiroz,Ryan Quiroz,Jonathan Iaconelli,Jonathan Iaconelli,Rakesh Karmacharya,Rakesh Karmacharya,Rakesh Karmacharya,Nicola Tolliday,Paul A. Clemons,M. a. l. c. o. l. m. a. S. Moore,Andrew M. Stern,Andrew M. Stern,Alykhan F. Shamji,Benjamin L. Ebert,Benjamin L. Ebert,Todd R. Golub,Todd R. Golub,Todd R. Golub,Noopur Raje,David T. Scadden,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber +50 more
TL;DR: Differences in Eg5-microtubule binding between malignant and normal blood cells may be exploited to treat multiple myeloma and indicate that unbiased chemical biology approaches can identify therapeutic strategies unanticipated by prior knowledge of protein targets.
Journal ArticleDOI
BCL2 blockade overcomes MCL1 resistance in multiple myeloma.
Ka Tat Siu,Cherrie Huang,Cristina Panaroni,Kenta Mukaihara,Keertik Fulzele,Rosemary Soucy,Cassandra Ann Thorburn,Justin Cidado,Lisa Drew,Shrikanta Chattopadhyay,Noopur Raje +10 more
TL;DR: The results indicate that AZD5991 has promising singleagent activity, but it would be prudent to study it in combination with other anti-MM therapies, as well as to investigate the mechanistic underpinning of MCL1 inhibition in MM.
Journal ArticleDOI
Arachidonic Acid Induces Ferroptosis-Mediated Cell-Death in Multiple Myeloma
Cristina Panaroni,Keertik Fulzele,Rosemary Soucy,Ka Tat Siu,Kenta Mukaihara,Cherrie Huang,Shrikanta Chattopadhyay,Shrikanta Chattopadhyay,Noopur Raje +8 more
TL;DR: A vicious cycle in which early stage MM cells and BM adipocytes support each other's growth is demonstrated in which increasing AA levels around MM cells may decrease MM progression.