F
Francois Mercier
Researcher at Harvard University
Publications - 40
Citations - 2700
Francois Mercier is an academic researcher from Harvard University. The author has contributed to research in topics: Haematopoiesis & Bone marrow. The author has an hindex of 17, co-authored 39 publications receiving 2053 citations. Previous affiliations of Francois Mercier include Montreal Chest Institute & McGill University.
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Journal ArticleDOI
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
Ninib Baryawno,Dariusz Przybylski,Monika S. Kowalczyk,Youmna Kfoury,Nicolas Severe,Karin Gustafsson,Konstantinos D. Kokkaliaris,Francois Mercier,Marcin Tabaka,Matan Hofree,Danielle Dionne,Ani Papazian,Dongjun Lee,Orr Ashenberg,Ayshwarya Subramanian,Eeshit Dhaval Vaishnav,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,David T. Scadden +19 more
TL;DR: The data suggest that tissue stroma responds to malignant cells by disadvantaging normal parenchymal cells, and provides a comprehensive bone marrow cell census and experimental support for cancer cell crosstalk with specific stromal elements to impair normal tissue function and thereby enable emergent cancer.
Journal ArticleDOI
Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice
Eda Yildirim,James E. Kirby,Diane E. Brown,Francois Mercier,Ruslan I. Sadreyev,David T. Scadden,Jeannie T. Lee +6 more
TL;DR: It is proposed that Xist loss results in X reactivation and consequent genome-wide changes that lead to cancer, thereby causally linking the X chromosome to cancer in mice.
Journal ArticleDOI
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
David B. Sykes,Youmna Kfoury,Francois Mercier,Mathias Wawer,Jason M. Law,Mark K. Haynes,Timothy A. Lewis,Amir Schajnovitz,Esha Jain,Dongjun Lee,Hanna Meyer,Kerry A. Pierce,Nicola Tolliday,Anna Waller,Steven James Ferrara,Ashley Eheim,Detlef Stoeckigt,Katrina Maxcy,Julien Cobert,Jacqueline Bachand,Brian A. Szekely,Siddhartha Mukherjee,Larry A. Sklar,Joanne Kotz,Clary B. Clish,Ruslan I. Sadreyev,Paul A. Clemons,Andreas Janzer,Stuart L. Schreiber,David T. Scadden +29 more
TL;DR: The unanticipated discovery that inhibition of the enzyme dihydroorotate dehydrogenase (DHODH) enables myeloid differentiation in human and mouse AML models demonstrates the role of DHODH as a metabolic regulator of differentiation and point to its inhibition as a strategy for overcoming differentiation blockade in AML.
Journal ArticleDOI
The bone marrow at the crossroads of blood and immunity
TL;DR: The organization of regulatory elements in the bone marrow is reviewed and how these elements provide a dynamic means for the host to modulate stem cell and adaptive immune cell responses to physiological challenges are discussed.
Journal ArticleDOI
AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias
Stephen M. Sykes,Steven W. Lane,Lars Bullinger,Demetrios Kalaitzidis,Rushdia Z. Yusuf,Borja Saez,Francesca Ferraro,Francois Mercier,Harshabad Singh,Kristina Brumme,Sanket S. Acharya,Claudia Scholl,Zuzana Tothova,Eyal C. Attar,Stefan Fröhling,Ronald A. DePinho,D. Gary Gilliland,Scott A. Armstrong,David T. Scadden +18 more
TL;DR: In this article, the authors show a converse role for AKT/FOXOs in acute myeloid leukemia (AML) and demonstrate that AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tumor suppressors.