Elke Bräuer-Krisch

TL;DR: Results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.

TL;DR: GBNs exhibit an interesting potential for image-guided radiotherapy since the radiosensitizing effect of GBNs can be activated by X-ray microbeams when the gadolinium content is enough in the tumor and low in the surrounding healthy tissue.

TL;DR: The paper highlights the history of MRT including salient biological findings after microbeam irradiation with emphasis on the vascular components and the tolerance of the central nervous system and details on experimental and theoretical dosimetry of microbeams, core issues and possible therapeutic applications of M RT are presented.

TL;DR: It is shown for the first time that preferential damage of MRT to tumor vessels versus preservation of radioresistant normal brain vessels contributes to the efficient palliation of 9L gliosarcomas in rats.

TL;DR: The ratio of peak-to-valley doses (PVDR's) in the composite dose distribution has been found to be strongly correlated with the normal tissue tolerance and the therapeutic effect of MRT.