E
Ellen Orthey
Publications - 4
Citations - 1180
Ellen Orthey is an academic researcher. The author has contributed to research in topics: Inflammation & Desmin. The author has an hindex of 2, co-authored 2 publications receiving 960 citations.
Papers
More filters
Journal ArticleDOI
Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
TL;DR: The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.
Journal ArticleDOI
Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke.
Mathias Gelderblom,Anna Weymar,Christian Bernreuther,Joachim Velden,Priyadharshini Arunachalam,Karin Steinbach,Ellen Orthey,Thiruma V. Arumugam,Frank Leypoldt,Olga Simova,Vivien Thom,Manuel A. Friese,Immo Prinz,Christoph Hölscher,Markus Glatzel,Thomas Korn,Christian Gerloff,Eva Tolosa,Tim Magnus +18 more
TL;DR: It is proposed that selective targeting of IL-17A signaling might provide a new therapeutic option for the treatment of stroke, and this aspect of the inflammatory cascade is also relevant in the human brain.
Journal ArticleDOI
A human CRYABR120G Desmin-related cardiomyopathy cellular model
Niels Pietsch,Antonietta Fazio,Jiancheng Cheng,Ellen Orthey,Elisabeth Krämer,Saskia Schlossarek,Lucie Carrier,Sonia R. Singh +7 more
Journal ArticleDOI
JAK1 Inhibitors reduce CRYABR120G aggregates in rat and human cardiomyocytes
E. Alizoti,Lysa Michler,Ellen Orthey,Hanna Osinska,James Gulick,Birgit Klampe,Thomas G. Schulze,Arne Hansen,Saskia Schlossarek,Lucy Carrier,Patrick M. McLendon,Jeffrey Robbins,Sonia R. Singh +12 more
TL;DR: In this article , the authors identified Janus kinase 1 (JAK1) as a novel effector of cardiac protein aggregation by a high-throughput screen and showed that reducing protein aggregates attenuates DRM.