D
Dominic A. Siler
Researcher at Oregon Health & Science University
Publications - 29
Citations - 2404
Dominic A. Siler is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 11, co-authored 18 publications receiving 2029 citations. Previous affiliations of Dominic A. Siler include California State University, Long Beach & National Institutes of Health.
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Journal ArticleDOI
Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
TL;DR: The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.
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Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Sung-Chun Tang,Thiruma V. Arumugam,Thiruma V. Arumugam,Xiangru Xu,Aiwu Cheng,Mohamed R. Mughal,Dong-Gyu Jo,Dong-Gyu Jo,Justin D. Lathia,Dominic A. Siler,Srinivasulu Chigurupati,Xin Ouyang,Tim Magnus,Tim Magnus,Simonetta Camandola,Mark P. Mattson,Mark P. Mattson +16 more
TL;DR: It is reported that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-γ stimulation and energy deprivation, establishing a proapoptotic signaling pathway for TLR1 and -3 in neurons that may render them vulnerable to ischemic death.
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Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride
Andrew S. Terker,Chong Zhang,Chong Zhang,James A. McCormick,Rebecca A. Lazelle,Chengbiao Zhang,Nicholas P. Meermeier,Dominic A. Siler,Hae J. Park,Yi Fu,David M. Cohen,Alan M. Weinstein,Wen-Hui Wang,Chao Ling Yang,David H. Ellison +14 more
TL;DR: It is shown that dietary potassium deficiency activates NCC, even in the setting of high salt intake, thereby causing sodium retention and a rise in blood pressure, and that DCT cells, like adrenal cells, sense potassium via membrane voltage.
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Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal
Sung-Chun Tang,Justin D. Lathia,Pradeep K. Selvaraj,Dong-Gyu Jo,Dong-Gyu Jo,Mohamed R. Mughal,Aiwu Cheng,Dominic A. Siler,William R. Markesbery,Thiruma V. Arumugam,Mark P. Mattson,Mark P. Mattson +11 more
TL;DR: It is reported that TLR4 expression increases in neurons when exposed to amyloid beta-peptide (Abeta1-42) or the lipid peroxidation product 4-hydroxynonenal (HNE), and this finding is identified as a potential therapeutic target for AD.
Journal ArticleDOI
Intracisternal Administration of Tissue Plasminogen Activator Improves Cerebrospinal Fluid Flow and Cortical Perfusion After Subarachnoid Hemorrhage in Mice
Dominic A. Siler,Jorge A. Gonzalez,Ruikang K. Wang,Justin S. Cetas,Justin S. Cetas,Nabil J. Alkayed +5 more
TL;DR: In this paper, the effects of intracisternal injection of recombinant tissue plasminogen activator (tPA) were evaluated in mice subjected to subarachnoid hemorrhage.