C
Concezio Di Rocco
Researcher at Catholic University of the Sacred Heart
Publications - 145
Citations - 5269
Concezio Di Rocco is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Hydrocephalus & Craniosynostosis. The author has an hindex of 34, co-authored 145 publications receiving 4755 citations. Previous affiliations of Concezio Di Rocco include Sapienza University of Rome & Jikei University School of Medicine.
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Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
MicroRNA profiling in human medulloblastoma
Elisabetta Ferretti,Enrico De Smaele,Agnese Po,Lucia Di Marcotullio,Emanuele Tosi,Maria Salome Bezerra Espinola,Concezio Di Rocco,Riccardo Riccardi,Felice Giangaspero,Alessio Farcomeni,Italo Nofroni,Pietro Laneve,Ubaldo Gioia,Ubaldo Gioia,Elisa Caffarelli,Irene Bozzoni,Irene Bozzoni,Irene Bozzoni,Isabella Screpanti,Isabella Screpanti,Alberto Gulino +20 more
TL;DR: Specific microRNA expression patterns which distinguish medulloblastoma differing in histotypes, in molecular features and in disease‐risk stratification are identified, and misregulated microRNAs expression profiles characterize human medullOBlastomas, and may provide potential targets for novel therapeutic strategies.
Journal ArticleDOI
Cytogenetic Prognostication Within Medulloblastoma Subgroups
David Shih,Paul A. Northcott,Marc Remke,Andrey Korshunov,Vijay Ramaswamy,Marcel Kool,Betty Luu,Yuan Yao,Xin Wang,Adrian M. Dubuc,Livia Garzia,John Peacock,Stephen C. Mack,Xiaochong Wu,Adi Rolider,A. Sorana Morrissy,Florence M.G. Cavalli,David T.W. Jones,Karel Zitterbart,Claudia C. Faria,Claudia C. Faria,Ulrich Schüller,Leos Kren,Toshihiro Kumabe,Teiji Tominaga,Young Shin Ra,Miklós Garami,Peter Hauser,Jennifer A. Chan,Shenandoah Robinson,László Bognár,Almos Klekner,Ali G. Saad,Linda M. Liau,Steffen Albrecht,Adam M. Fontebasso,Giuseppe Cinalli,Pasqualino De Antonellis,Massimo Zollo,Michael K. Cooper,Reid C. Thompson,Simon Bailey,Janet C. Lindsey,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Stephen W. Scherer,Joanna J. Phillips,Nalin Gupta,Xing Fan,Karin M. Muraszko,Rajeev Vibhakar,Charles G. Eberhart,Maryam Fouladi,Boleslaw Lach,Shin Jung,Robert J. Wechsler-Reya,Michelle Fèvre-Montange,Anne Jouvet,Nada Jabado,Ian F. Pollack,William A. Weiss,Ji Yeoun Lee,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Jeffrey R. Leonard,Joshua B. Rubin,Carmen de Torres,Cinzia Lavarino,Jaume Mora,Yoon Jae Cho,Uri Tabori,James M. Olson,Amar Gajjar,Roger J. Packer,Stefan Rutkowski,Scott L. Pomeroy,Pim J. French,Nanne K. Kloosterhof,Johan M. Kros,Erwin G. Van Meir,Steven C. Clifford,Franck Bourdeaut,Olivier Delattre,François Doz,François Doz,Cynthia Hawkins,David Malkin,Wiesława Grajkowska,Marta Perek-Polnik,Eric Bouffet,James T. Rutka,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor +95 more
TL;DR: A small panel of cytogenetic biomarkers is identified that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials.
Journal ArticleDOI
Hedgehog controls neural stem cells through p53-independent regulation of Nanog
Agnese Po,Elisabetta Ferretti,Evelina Miele,Enrico De Smaele,Arianna Paganelli,Gianluca Canettieri,Sonia Coni,Lucia Di Marcotullio,Mauro Biffoni,Luca Massimi,Concezio Di Rocco,Isabella Screpanti,Alberto Gulino +12 more
TL;DR: It is shown that Nanog is highly expressed in SCs from postnatal cerebellum and medulloblastoma, and acts as a critical mediator of Hh‐driven self‐renewal, which represents a crucial component of an integrated circuitry determining cell fate decision and involved in the maintenance of cancer SCs.
Journal ArticleDOI
Laminotomy and total reconstruction of the posterior spinal arch for spinal canal surgery in childhood
TL;DR: Indications in infants and children, the surgical technique, and the postoperative management are presented and the goal is preservation of the normal architecture of the spine in patients who are still developing.