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Seon Jin Lee
Researcher at Brigham and Women's Hospital
Publications - 30
Citations - 4636
Seon Jin Lee is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 18, co-authored 22 publications receiving 4046 citations. Previous affiliations of Seon Jin Lee include University of Pittsburgh & Korea Research Institute of Bioscience and Biotechnology.
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Journal ArticleDOI
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Kiichi Nakahira,Jeffrey A. Haspel,Jeffrey A. Haspel,Vijay A. K. Rathinam,Seon Jin Lee,Tamas Dolinay,Hilaire C. Lam,Joshua A. Englert,Marlene Rabinovitch,Manuela Cernadas,Hong Pyo Kim,Hong Pyo Kim,Katherine A. Fitzgerald,Stefan W. Ryter,Augustine M.K. Choi +14 more
TL;DR: This study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondria integrity and cytosolic translocation of mitochondrial DNA in response to lipopolysaccharide and ATP in macrophages.
Journal ArticleDOI
Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Zhi Hua Chen,Hong Pyo Kim,Hong Pyo Kim,Frank C. Sciurba,Seon Jin Lee,Seon Jin Lee,Carol Feghali-Bostwick,Donna B. Stolz,Rajiv Dhir,Rodney J. Landreneau,Mathew J. Schuchert,Samuel A. Yousem,Kiichi Nakahira,Kiichi Nakahira,Joseph M. Pilewski,Janet S. Lee,Yingze Zhang,Stefan W. Ryter,Stefan W. Ryter,Augustine M.K. Choi +19 more
TL;DR: A critical role for Egr-1 is demonstrated in promoting autophagy and apoptosis in response to cigarette smoke exposure in vitro and in vivo, suggesting novel therapeutic targets for the treatment of cigarette smoke induced lung injury.
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Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
Zhi Hua Chen,Hilaire C. Lam,Hilaire C. Lam,Yang Jin,Hong Pyo Kim,Hong Pyo Kim,Jiaofei Cao,Jiaofei Cao,Seon Jin Lee,Emeka Ifedigbo,Harikrishnan Parameswaran,Stefan W. Ryter,Augustine M.K. Choi +12 more
TL;DR: A pivotal role is demonstrated for the autophagic proteinLC3B in CS-induced apoptosis and emphysema, suggestive of novel therapeutic targets for COPD treatment and a mechanism by which LC3B, through interactions with Cav-1 and Fas, can regulate apoptosis.
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Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-β1
TL;DR: It is shown that kidneys from mice deficient in autophagic protein Beclin 1 exhibited profibrotic phenotype, with increased collagen deposition, and data indicate that Col-I and aggregated, insoluble procollagen I undergo intracellular degradation via autophagy.
Journal ArticleDOI
Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension
Seon Jin Lee,Akaya Smith,Lanping Guo,Tero-Pekka Alastalo,Molong Li,Hirofumi Sawada,Xiaoli Liu,Zhi Hua Chen,Emeka Ifedigbo,Yang Jin,Carol Feghali-Bostwick,Stefan W. Ryter,Hong Pyo Kim,Hong Pyo Kim,Marlene Rabinovitch,Augustine M.K. Choi +15 more
TL;DR: The results suggest that autophagic protein LC3B exerts a protective function during the pathogenesis of PH, through the regulation of hypoxic cell proliferation.