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Emiliana Borrelli
Researcher at University of California, Irvine
Publications - 131
Citations - 14627
Emiliana Borrelli is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Dopamine receptor D2 & Dopaminergic. The author has an hindex of 62, co-authored 128 publications receiving 13836 citations. Previous affiliations of Emiliana Borrelli include University of Strasbourg & Collège de France.
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Structure and function of dopamine receptors
TL;DR: This review focuses on the pharmacological and biochemical features shared by the dopamine receptors and their coupling to secondary messenger pathways and their physiological function based upon studies using pharmacological tools, specific brain lesions and, more recently, genetically modified animal models.
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Distinct functions of the two isoforms of dopamine D2 receptors
Alessandro Usiello,Ja Hyun Baik,Françoise Rougé-Pont,Roberto Picetti,Andrée Dierich,Marianne LeMeur,Pier Vincenzo Piazza,Emiliana Borrelli +7 more
TL;DR: It is shown that these receptors have distinct functions in vivo; D2L acts mainly at postsynaptic sites and D2S serves presynaptic autoreceptor functions, uncovering a circuit of signalling interference between dopamine receptors.
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Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors.
Ja Hyun Baik,Roberto Picetti,Adolfo Saiardi,G. Thiriet,Andrée Dierich,Antoine Depaulis,Marianne Le Meur,Emiliana Borrelli +7 more
TL;DR: This study shows that D2 receptors have a key role in the dopaminergic control of nervous function, using homologous recombination to generate D2-receptor-deficient mice, which have therapeutic potential as a model for investigating and correcting dysfunctions of the dopamine system.
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CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription.
TL;DR: Using PCR and RNAase protection analysis, this gene, termed CREM, is isolated from a mouse pituitary cDNA library and three mRNA isoforms are identified that appear to be obtained by differential cell-specific splicing.
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Decoding the Epigenetic Language of Neuronal Plasticity
TL;DR: The molecular pathways underlying chromatin transitions, the presence of an "epigenetic indexing code," and how central findings accumulating at an exponential pace in the field of epigenetics are conceptually changing the perspective of adult brain function are discussed.