E
Emily M. Hatch
Researcher at Fred Hutchinson Cancer Research Center
Publications - 25
Citations - 2200
Emily M. Hatch is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Lamin & Nuclear membrane. The author has an hindex of 13, co-authored 23 publications receiving 1707 citations. Previous affiliations of Emily M. Hatch include Salk Institute for Biological Studies & Stanford University.
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Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei
TL;DR: This study shows that NE collapse is a key event underlying MN dysfunction and establishes a link between aberrant NE organization and aneuploidy, suggesting that disrupted MN could be a useful objective biomarker for genomic instability in solid tumors.
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Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
Jerome Mertens,Apuã C. M. Paquola,Manching Ku,Emily M. Hatch,Lena Böhnke,Shauheen Ladjevardi,Sean McGrath,Benjamin C. Campbell,Hyungjun Lee,Joseph R. Herdy,J. Tiago Gonçalves,Tomohisa Toda,Yongsung Kim,Jürgen Winkler,Jun Yao,Martin W. Hetzer,Fred H. Gage +16 more
TL;DR: Results show that iNs retain important aging-related signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC as an important factor in human aging.
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Cep152 interacts with Plk4 and is required for centriole duplication
TL;DR: Cep152, the orthologue of Drosophila Asterless, is a PlK4 target that functions with Plk4 in centriole assembly.
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Transient nuclear envelope rupturing during interphase in human cancer cells
TL;DR: Using live cell imaging, the existence of a NE instability that has the potential to change the genomic landscape of cancer cells is uncovered, associated with the mislocalization of nucleoplasmic and cytoplasmic proteins and, in the most extreme cases, the entrapment of cytopLasmic organelles in the nuclear interior.
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Nuclear envelope rupture is induced by actin-based nucleus confinement.
Emily M. Hatch,Martin W. Hetzer +1 more
TL;DR: Hatch and Hetzer show that nuclear envelope rupture in cancer cells is caused by defects in lamina organization, resulting in an increase in intranuclear pressure from actin-based nucleus confinement.