M
Martin W. Hetzer
Researcher at Salk Institute for Biological Studies
Publications - 109
Citations - 11548
Martin W. Hetzer is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Nuclear pore & Nucleoporin. The author has an hindex of 55, co-authored 104 publications receiving 10062 citations. Previous affiliations of Martin W. Hetzer include University of Düsseldorf & University of Vienna.
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Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei
TL;DR: This study shows that NE collapse is a key event underlying MN dysfunction and establishes a link between aberrant NE organization and aneuploidy, suggesting that disrupted MN could be a useful objective biomarker for genomic instability in solid tumors.
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Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
Jerome Mertens,Apuã C. M. Paquola,Manching Ku,Emily M. Hatch,Lena Böhnke,Shauheen Ladjevardi,Sean McGrath,Benjamin C. Campbell,Hyungjun Lee,Joseph R. Herdy,J. Tiago Gonçalves,Tomohisa Toda,Yongsung Kim,Jürgen Winkler,Jun Yao,Martin W. Hetzer,Fred H. Gage +16 more
TL;DR: Results show that iNs retain important aging-related signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC as an important factor in human aging.
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Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells
TL;DR: It is shown that NPCs, unlike other nuclear structures, do not turn over in differentiated cells, and that a subset of nucleoporins is oxidatively damaged in old cells, suggesting that the accumulation of damage at the NPC might be a crucial aging event.
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Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures
Brandon H. Toyama,Jeffrey N. Savas,Sung Kyu Park,Michael S. Harris,Michael S. Harris,Nicholas T. Ingolia,John R. Yates,Martin W. Hetzer +7 more
TL;DR: The identification of a long-lived proteome reveals cellular components that are at increased risk for damage accumulation, linking long-term protein persistence to the cellular aging process.
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The Conserved Nup107-160 Complex Is Critical for Nuclear Pore Complex Assembly
Tobias C. Walther,Annabelle Alves,Helen Pickersgill,Isabelle Loïodice,Martin W. Hetzer,Vincent Galy,Bastian B Hülsmann,Thomas Köcher,Matthias Wilm,Terence D Allen,Iain W. Mattaj,Valérie Doye +11 more
TL;DR: A stepwise model is proposed in which postmitotic NPC assembly initiates on chromatin via early recruitment of the Nup107-160 complex, which is conserved in higher eukaryotes and prevents association of FG-repeat nucleoporins with chromatin.