E
Emily O. Kerr
Researcher at University of Washington
Publications - 14
Citations - 2850
Emily O. Kerr is an academic researcher from University of Washington. The author has contributed to research in topics: Saccharomyces cerevisiae & Calorie restriction. The author has an hindex of 11, co-authored 14 publications receiving 2640 citations.
Papers
More filters
Journal ArticleDOI
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Matt Kaeberlein,R. Wilson Powers,Kristan K. Steffen,Eric A. Westman,Di Hu,Nick Dang,Emily O. Kerr,Kathryn T. Kirkland,Stanley Fields,Brian K. Kennedy +9 more
TL;DR: It is proposed that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast.
Journal ArticleDOI
Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4
Kristan K. Steffen,Vivian L. MacKay,Emily O. Kerr,Mitsuhiro Tsuchiya,Di Hu,Lindsay A. Fox,Nick Dang,Elijah D. Johnston,Jonathan A. Oakes,Bie N. Tchao,Diana N. Pak,Stanley Fields,Brian K. Kennedy,Matt Kaeberlein +13 more
TL;DR: It is shown that a specific reduction of 60S ribosomal subunit levels slows aging in yeast, and genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and Gcn4 activation extend yeast life span by similar mechanisms.
Journal ArticleDOI
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
Mark A. McCormick,Joe R. Delaney,Mitsuhiro Tsuchiya,Scott Tsuchiyama,Anna Shemorry,Sylvia Sim,Annie Chou,Umema Ahmed,Daniel B. Carr,Christopher J. Murakami,Jennifer Schleit,George L. Sutphin,Brian M. Wasko,Christopher F. Bennett,Adrienne M. Wang,Brady Olsen,Richard P. Beyer,Theodor K. Bammler,Donna Prunkard,Simon C. Johnson,Juniper K. Pennypacker,Elroy H. An,Arieanna C. Anies,Anthony S. Castanza,Eunice Choi,Nick Dang,Shiena Enerio,Marissa Fletcher,Lindsay A. Fox,Sarani Goswami,Sean Higgins,Molly A. Holmberg,Di Hu,Jessica Hui,Monika Jelic,Ki Soo Jeong,Elijah D. Johnston,Emily O. Kerr,Jin Kim,Diana Kim,Katie Kirkland,Shannon Klum,Soumya Kotireddy,Eric C. Liao,Michael Lim,Michael S. Lin,Winston Lo,Dan Lockshon,Hillary Miller,Richard M. Moller,Brian Muller,Jonathan A. Oakes,Diana N. Pak,Zhao Jun Peng,Kim M. Pham,Tom Pollard,Prarthana Pradeep,Dillon Pruett,Dilreet Rai,Brett Robison,Ariana A. Rodriguez,Bopharoth Ros,Michael Sage,Manpreet K. Singh,Erica D. Smith,Katie Snead,Amrita Solanky,Benjamin L. Spector,Kristan K. Steffen,Bie N. Tchao,Marc K. Ting,Helen Vander Wende,Dennis Wang,K. Linnea Welton,Eric A. Westman,Rachel B. Brem,Xinguang Liu,Yousin Suh,Yousin Suh,Zhongjun Zhou,Matt Kaeberlein,Brian K. Kennedy,Brian K. Kennedy +82 more
TL;DR: A systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion strains demonstrated a significant conservation in longevity pathways between yeast and C. elegans, and mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended lifespan.
Journal ArticleDOI
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
Erica D. Smith,Mitsuhiro Tsuchiya,Lindsay A. Fox,Nick Dang,Di Hu,Emily O. Kerr,Elijah D. Johnston,Bie N. Tchao,Diana N. Pak,K. Linnea Welton,Daniel E. L. Promislow,James H. Thomas,Matt Kaeberlein,Brian K. Kennedy +13 more
TL;DR: Findings indicate that the genetic component of life span determination is significantly conserved between divergent eukaryotic species, and suggest pathways that are likely to play a similar role in mammalian aging.
Journal ArticleDOI
Increased life span due to calorie restriction in respiratory-deficient yeast.
Matt Kaeberlein,Di Hu,Emily O. Kerr,Mitsuhiro Tsuchiya,Eric A. Westman,Nick Dang,Stanley Fields,Brian K. Kennedy +7 more
TL;DR: It is demonstrated that respiration is not required for the longevity benefits of CR in yeast, and shows that nicotinamide inhibits life span extension by CR through a Sir2-independent mechanism, and suggests that CR acts through a conserved, Sir2 -independent mechanism in both PSY316 and BY4742.