Ennio Tasciotti

TL;DR: The methods developed in this study provide effective means to fabricate mesoporous silicon particles according to the principles of rational design for therapeutic vectors and to characterize the distribution of nanoparticles within the porous matrix.

TL;DR: A simple method to provide mesoporous silica nanoparticles (MSN) with a proteolytic surface was developed, which increased particle uptake in endothelial, macrophage, and cancer cell lines with minimal impact on cellular viability and showed an increased ability to digest and diffuse in tumor ECM in vitro and in vivo.

TL;DR: A novel family of cell-penetrating peptides named Vectocell peptides, originating from human heparin binding proteins and/or anti-DNA antibodies, once conjugated to a therapeutic molecule, can deliver the molecule to either the cytoplasm or the nucleus of mammalian cells.

TL;DR: It is demonstrated that PRP and PPP represented a viable alternative to FBS containing media for the cryo-preservation of MSC from human and rat BM and ucPRP showed greater potency than adult PRP, PPP from either source, or indeed than combinations of either recombinant growth factors or chemokines previously shown to stimulate chemotactic migration of M SC.

TL;DR: A high level of structural mimicry by the scaffold to the composition and structure of human osteogenic niche that translated to faster and more efficient osteoinduction in vivo is confirmed, suggesting such a biomaterial may have great utility in future clinical applications where bone regeneration is required.