Ennio Tasciotti

TL;DR: Localized inhibition of P2X7R for two weeks can be associated with reduced number of microglia and attenuated bladder hyperexcitability mediated by downregulation of urothelial P2x3R in rats with neurogenic bladder dysfunction and independently of locomotor improvements.

TL;DR: Porous silicon nanodisks (PSD) may be a promising injectable, multifunctional nanovector for biomedical application and surface-enhanced raman scattering (SERS) using PSD/AuNR as particle substrates was demonstrated.

TL;DR: The presented strategy establishes the basis of a versatile scaffold for the controlled release of small molecules and for culturing mesenchymal stem cells for regenerative medicine applications.

TL;DR: The data demonstrate that the isolation protocol identifies and validates mesenchymal stem cells with superior clonal, proliferative, and developmental potential from cortical bone compared to the bone marrow niche although marrow persists as the typical source for mesenchyl stem cells both in the literature and current pre-clinical therapies.

TL;DR: The role of inflammation in the different steps of tumor development and the strategies based on the use of nanoparticles that exploit the inflammatory pathways in order to selectively target the tumor-associated microenvironment for therapeutic and diagnostic purposes are discussed.