Enrico O. Purisima

TL;DR: Findings support a rational clinical development opportunity for the compound in cancer indications or treatments where MCL-1 contributes to resistance to cell killing.

TL;DR: The results suggest that the endopeptidase activity of cathepsin B is an evolutionary remnant since, as a consequence of its membership in the papain family, the propeptide must be able to bind unobstructed through the full length of the active site cleft.

TL;DR: It is shown that the limiting factor in accuracy is not the evaluation of integrals involving the interaction between boundary elements but rather a proper estimation of the self‐polarization of a patch upon itself, and a sum rule is derived that allows us to calculate this important self‐ polarization term in a self‐consistent and simple way.

TL;DR: The sensitized protein-protein interface afforded by the p14(Y56A) mutation identified here has practical applications in screening-based discovery of first-generation small-molecule hits for further development into specific modulators of the mitogen-activated protein kinase signaling pathway.

TL;DR: Gene ontology analysis reveals that the genes with higher cis-regulation complexity are more coordinately regulated by TFs at the transcriptional level and by miRNAs at the post-transcriptional level, which is a potentially novel discovery of mechanism for coordinated regulation of gene expression.