L
Leonie A. Cluse
Researcher at Peter MacCallum Cancer Centre
Publications - 29
Citations - 3428
Leonie A. Cluse is an academic researcher from Peter MacCallum Cancer Centre. The author has contributed to research in topics: Vorinostat & Histone deacetylase. The author has an hindex of 21, co-authored 27 publications receiving 3087 citations. Previous affiliations of Leonie A. Cluse include Walter and Eliza Hall Institute of Medical Research & Royal Melbourne Hospital.
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Journal ArticleDOI
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
Mai Nguyen,Richard C. Marcellus,Anne Roulston,Mark F. Watson,Lucile Serfass,S.R. Murthy Madiraju,Daniel Goulet,Jean Viallet,Laurent Bélec,Xavier Billot,Stephane Acoca,Enrico O. Purisima,Adrian Wiegmans,Leonie A. Cluse,Ricky W. Johnstone,Pierre Beauparlant,Gordon C. Shore +16 more
TL;DR: Findings support a rational clinical development opportunity for the compound in cancer indications or treatments where MCL-1 contributes to resistance to cell killing.
Journal ArticleDOI
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Megan J. Bywater,Gretchen Poortinga,Gretchen Poortinga,Elaine Sanij,Elaine Sanij,Nadine Hein,Abigail Peck,Carleen Cullinane,Meaghan Wall,Leonie A. Cluse,Denis Drygin,Kenna Anderes,Nanni Huser,Chris Proffitt,Josh Bliesath,Mustapha Haddach,Michael K. Schwaebe,David M. Ryckman,William G. Rice,Clemens A. Schmitt,Clemens A. Schmitt,Scott W. Lowe,Ricky W. Johnstone,Ricky W. Johnstone,Richard B. Pearson,Grant A. McArthur,Ross D. Hannan +26 more
TL;DR: It is shown that rDNA transcription can be therapeutically targeted with the small molecule CX-5461 to selectively kill B-lymphoma cells in vivo while maintaining a viable wild-type B cell population.
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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
Andrew W. Roberts,Lorraine Robb,Steven Rakar,Lynne Hartley,Leonie A. Cluse,Nicos A. Nicola,Donald Metcalf,Douglas J. Hilton,Warren S. Alexander +8 more
TL;DR: The data suggest that SOCS3 is required for placental development but dispensable for normal hematopoiesis in the mouse embryo.
Journal ArticleDOI
SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis
Ben A. Croker,Donald Metcalf,Lorraine Robb,Wei Wei,Sandra Mifsud,Ladina DiRago,Leonie A. Cluse,Kate D. Sutherland,Lynne Hartley,Emily L Williams,Jian-Guo Zhang,Douglas J. Hilton,Nicos A. Nicola,Warren S. Alexander,Andrew W. Roberts +14 more
TL;DR: It is concluded that SOCS3 is a key negative regulator of G- CSF signaling in myeloid cells and that this is of particular significance during G-CSF-driven emergency granulopoiesis.
Journal ArticleDOI
BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.
Simon J. Hogg,Stephin J. Vervoort,Sumit Deswal,Christopher J. Ott,Jason Li,Leonie A. Cluse,Paul A. Beavis,Phillip K. Darcy,Benjamin P. Martin,Andrew Spencer,Anna K. Traunbauer,Irina Sadovnik,Karin Bauer,Peter Valent,James E. Bradner,Johannes Zuber,Jake Shortt,Ricky W. Johnstone,Ricky W. Johnstone +18 more
TL;DR: It is found that maximal therapeutic effects of BETi in a Myc-driven B cell lymphoma model required an intact host immune system and mechanistic insight into the transcriptional regulation of CD274 is provided.