Sylvia Ortmann

TL;DR: It is shown that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness, and the cannabinoid system is an essential endogenous regulator of energy homeostasis via central orexigenic as well as peripheral lipogenic mechanisms and might therefore represent a promising target to treat diseases characterized by impaired energy balance.

TL;DR: Hibernation and daily torpor are found in small mammals inhabiting temperate as well as tropical climates, which indicates that this behaviour is not primarily aimed for cold defense, instead points to a general role of hypometabolism, as a measure to cope with a timely limited or seasonal bottleneck of energy supply.

TL;DR: Ghrelin causes long-term increases of food intake and, like AGRP, plays a previously unknown role as a suppressor of spontaneous physical activity, expanding the current model of food intakes to include mechanisms regulating physical activity may promote the understanding of two major etiological factors causing obesity.

TL;DR: It is proposed that very large body size does not automatically imply a digestive advantage, because long MRTs do not seem to be a characteristic of very large species only, and a potential body size limitation for herbivory on the lower end of the body size range is supported.

TL;DR: Data speak against a sustained decrease in food intake, body fat, or body weight gain following PYY3‐36 administration and make the previously suggested role of the hypothalamic melanocortin system unlikely as is the existence of PYY deficiency in human obesity.