Erhard Bremer

TL;DR: The crystal structure of EctD increases the understanding of the structural-functional relationship in an evolutionary conserved group of enzymes and exposes an intricate network of interactions between the enzyme and its ligands that collectively ensure the hydroxylation of the ectoine substrate in a position- and stereo-specific manner.

TL;DR: A striking difference between these chemically closely related compounds was observed: L-proline betaine was an excellent cold stress protectant, but did not provide heat stress protection, whereas the reverse was true for betonicine.

TL;DR: It is shown that cytR expression is negatively controlled by the CytR protein and positively affected by the cAMP/CAP complex and the previousty described mutation (cytR*) in the cloned cytR gene results in the phenotypic suppression of a CyTR operator mutation in the tsx P2 promoter.

TL;DR: The case described here, in which a protein-induced DNA bend is modulated by a second protein, may illustrate a mechanism that applies to other regulatory systems, and is indicated that the minimal DNA region required to obtain CytR regulation consists of a single binding site for each of cAMP-CRP andCytR.

TL;DR: It is shown that the transcription of the anabolic proBA and proI genes is controlled in response to proline limitation via a T-box-mediated termination/antitermination regulatory mechanism, a tRNA-responsive riboswitch.