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Eric D. Hawkins
Researcher at Eli Lilly and Company
Publications - 14
Citations - 3594
Eric D. Hawkins is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 11, co-authored 14 publications receiving 3237 citations.
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Journal ArticleDOI
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
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Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance
William L. Holland,Joseph T. Brozinick,Liping Wang,Eric D. Hawkins,Katherine M. Sargent,Yanqi Liu,Krishna K. Narra,Kyle L. Hoehn,Trina A. Knotts,Angela M. Siesky,Don H. Nelson,Sotirios K. Karathanasis,Greg K Fontenot,Morris J. Birnbaum,Scott A. Summers +14 more
TL;DR: It is demonstrated that the sphingolipid ceramide is a common molecular intermediate linking several different pathological metabolic stresses to the induction of insulin resistance, and enzymes required for ceramide synthesis are identified as therapeutic targets for combating insulin resistance caused by nutrient excess or glucocorticoid therapy.
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Disruption of Cortical Actin in Skeletal Muscle Demonstrates an Essential Role of the Cytoskeleton in Glucose Transporter 4 Translocation in Insulin-sensitive Tissues
TL;DR: Results provide the first evidence that actin cytoskeletal mechanics are an essential feature of the glucose transport process in intact skeletal muscle and support a distal actin-based role for N-WASP in insulin action in vivo.
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Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.
Thomas A. Engler,Henry,Sushant Malhotra,Brian Eugene Cunningham,Kelly Wayne Furness,Joseph T. Brozinick,Burkholder Timothy P,Michael P. Clay,Joshua Ryan Clayton,Clive Gideon Diefenbacher,Eric D. Hawkins,Philip W. Iversen,YiHong Burlingame Li,Terry D. Lindstrom,Angela Lynn Marquart,Mclean Johnathan Alexander,David Mendel,Elizabeth A. Misener,Daniel A. Briere,O'toole John Cunningham,Warren J. Porter,Queener S,Jon K. Reel,Owens Rebecca Anne,Richard A. Brier,Thomas E Eessalu,Wagner,Robert M. Campbell,Vaughn R +28 more
TL;DR: A series of potent and selective GSK3 inhibitors are discovered, 7-12 show oral activity in an in vivo model of type II diabetes, and 9 and 12 have desirable PK properties.
Journal ArticleDOI
A Predominant Role of Acyl-CoA:monoacylglycerol Acyltransferase-2 in Dietary Fat Absorption Implicated by Tissue Distribution, Subcellular Localization, and Up-regulation by High Fat Diet
Jingsong Cao,Eric D. Hawkins,Joseph T. Brozinick,Xiaoyu Liu,Hongxing Zhang,Paul Burn,Yuguang Shi +6 more
TL;DR: Immunohistological studies provided direct evidence that the enzyme is expressed not only in the villi, but also in the crypt regions of the small intestine, which suggests that MGAT2 expression occurs prior to the maturation of enterocytes.