An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors
Tingsheng Peng,Pingyu Zhang,Jeffery Liu,Theresa Nguyen,Svetlana Bolshakov,Roman Belousov,Eric D. Young,Xiaoke Wang,Kari J. Brewer,Delores H López-Terrada,Andre M. Oliveira,Alexander J. Lazar,Dina Lev +12 more
TLDR
These newly established cellular and xenograft models can facilitate investigation of liposarcomagenesis, dedifferentiation, and tumor progression and may lead to improved therapeutic strategies for patients afflicted by these unfavorable malignancies.About:
This article is published in Laboratory Investigation.The article was published on 2011-03-01 and is currently open access. It has received 70 citations till now.read more
Citations
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Journal ArticleDOI
Advances in sarcoma genomics and new therapeutic targets
Barry S. Taylor,Jordi Barretina,Jordi Barretina,Robert G. Maki,Cristina R. Antonescu,Samuel Singer,Marc Ladanyi +6 more
TL;DR: The core molecular determinants of sarcomagenesis are discussed and the emerging genomic and functional genetic approaches that, coupled with novel therapeutic strategies, have the potential to transform the care of patients with sarcoma are emphasized.
Journal ArticleDOI
Clinical and Molecular Approaches to Well-differentiated and Dedifferentiated Liposarcoma
Aimee M. Crago,Samuel Singer +1 more
TL;DR: Although complete surgical resection is currently the most effective treatment for WDLS and DDLS, the majority of patients with retroperitoneal liposarcoma will eventually have recurrence and die of disease.
Journal ArticleDOI
Axl as a mediator of cellular growth and survival
TL;DR: The oncogenic nature of Axl is demonstrated through its activation of signaling pathways involved in proliferation, migration, inhibition of apoptosis, and therapeutic resistance, which must be analyzed in a cell type-specific context.
Journal ArticleDOI
Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression.
Lucia Casadei,Lucia Casadei,Federica Calore,Chad J. Creighton,Michele Guescini,Kara Batte,Kara Batte,O. Hans Iwenofu,Abeba Zewdu,Abeba Zewdu,Danielle Braggio,Danielle Braggio,Kate Lynn J. Bill,Kate Lynn J. Bill,Paolo Fadda,Francesca Lovat,Gonzalo Lopez,Gonzalo Lopez,Pierluigi Gasparini,James L. Chen,James L. Chen,Raleigh D. Kladney,Raleigh D. Kladney,Gustavo Leone,Gustavo Leone,Dina Lev,Carlo M. Croce,Raphael E. Pollock,Raphael E. Pollock +28 more
TL;DR: The possibility that the pattern of circulating miRNAs may identify recurrence prior to radiological detectability is established, establishing the possibility that insight into disease outcome and as a possible approach to monitor treatment efficacy is provided.
Journal ArticleDOI
Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival
Antoine Italiano,Maud Toulmonde,Angela Cioffi,Nicolas Penel,N. Isambert,Emmanuelle Bompas,Florence Duffaud,Anna Patrikidou,Barbara Lortal,A. Le Cesne,J.-Y. Blay,Robert G. Maki,Robert G. Maki,Gary K. Schwartz,C. R. Antonescu,Samuel Singer,J.-M. Coindre,Binh Bui +17 more
TL;DR: Chemotherapy was associated with clinical benefit in 46% of patients with advanced WDLPS/DDLPS, and OS remains poor, even though visceral metastatic disease is less frequent than in other sarcomas.
References
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Book
Enzinger and Weiss's Soft Tissue Tumors
Sharon W. Weiss,John R. Goldblum +1 more
TL;DR: The Enzinger and Weiss's soft tissue tumors are described, a large number of which consist of "hard-to-reach granuloma-like deposits".
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Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O.
TL;DR: A fast and simple method to quantitate the extent of adipose conversion by staining the accumulated lipid with Oil red O and determining the amount of extracted dye at 510 nm is reported.
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Cyclin D-dependent kinases, INK4 inhibitors and cancer.
TL;DR: A series of mouse models have been developed to study the in vivo function of individual components of this pathway in both normal homeostasis and tumor development, and several novel molecules, such as Cdk inhibitors, are under development as potential anti-cancer drugs.
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Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
Peter Tontonoz,Samuel Singer,Barry M. Forman,Pasha Sarraf,Jonathan A. Fletcher,Christopher D.M. Fletcher,Regina P. Brun,Elisabetta Mueller,Soner Altiok,Heather Oppenheim,Ronald M. Evans,Bruce M. Spiegelman +11 more
TL;DR: PPAR gamma ligands such as thiazolidinediones and RXR-specific retinoids may be useful therapeutic agents for the treatment of liposarcoma, suggesting that the differentiation block in these cells can be overcome by maximal activation of the PPAR pathway.
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MDM2 — master regulator of the p53 tumor suppressor protein
TL;DR: Evidence for the existence of three highly conserved regions (CRs) shared by MDM2 proteins and MDMX proteins of different species is presented and potential uses of this knowledge in the fight against cancer are discussed.
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