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Erica A K DePasquale
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 21
Citations - 545
Erica A K DePasquale is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Kinome & Traumatic brain injury. The author has an hindex of 9, co-authored 18 publications receiving 324 citations. Previous affiliations of Erica A K DePasquale include University of Cincinnati & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data
Erica A K DePasquale,Erica A K DePasquale,Daniel Schnell,Pieter-Jan Van Camp,Pieter-Jan Van Camp,Iñigo Valiente-Alandi,Burns C. Blaxall,Burns C. Blaxall,H. Leighton Grimes,H. Leighton Grimes,Harinder Singh,Nathan Salomonis,Nathan Salomonis +12 more
TL;DR: The ability of DoubletDecon to identify synthetic, mixed-species, genetic, and cell-hashing cell doublets from scRNA-seq datasets of varying cellular complexity with a high sensitivity relative to alternative approaches is demonstrated.
Journal ArticleDOI
Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury
Christopher R. Dorsett,Jennifer L. McGuire,Erica A K DePasquale,Amanda E. Gardner,Candace L. Floyd,Robert E. McCullumsmith +5 more
TL;DR: Dysregulation of extracellular glutamate and glutamate uptake in the acute stage of TBI and how failure to resolve acute disruptions in glutamate homeostatic mechanisms may play a causal role in chronic cognitive symptoms after TBI are discussed.
Journal ArticleDOI
Abnormalities of signal transduction networks in chronic schizophrenia
Jennifer L. McGuire,Erica A K DePasquale,Adam J. Funk,Sinead M. O’Donnovan,Kathryn Hasselfeld,Shruti Marwaha,John H. Hammond,Vahram Hartounian,Vahram Hartounian,James H. Meador-Woodruff,Jarek Meller,Jarek Meller,Robert E. McCullumsmith +12 more
TL;DR: The data indicate subtle changes in kinase activity and regulation across an interlinked kinase network, suggesting signaling imbalances underlie the core symptoms of schizophrenia.
Journal ArticleDOI
cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes
Erica A K DePasquale,Erica A K DePasquale,Daniel Schnell,Phillip Dexheimer,Phillip Dexheimer,Kyle Ferchen,Kyle Ferchen,Stuart Hay,Kashish Chetal,Iñigo Valiente-Alandi,Burns C. Blaxall,Burns C. Blaxall,H. Leighton Grimes,Nathan Salomonis,Nathan Salomonis +14 more
TL;DR: It is demonstrated that cellHarmony has improved or equivalent performance to alternative label projection methods, is able to identify the likely cellular origins of malignant states, stratify patients into clinical disease subtypes from identified gene programs, resolve discrete disease networks impacting specific cell-types, and illuminate therapeutic mechanisms.
Journal ArticleDOI
Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression.
Christopher R. Dorsett,Jennifer L. McGuire,Tracy L. Niedzielko,Erica A K DePasquale,Jaroslaw Meller,Candace L. Floyd,Robert E. McCullumsmith +6 more
TL;DR: It is hypothesized that the primary mechanism for removal of glutamate from the extracellular space is altered after traumatic brain injury (TBI), and several kinases as likely to be involved in acute TBI are identified.