E
Erica Andersen-Nissen
Researcher at Fred Hutchinson Cancer Research Center
Publications - 28
Citations - 8921
Erica Andersen-Nissen is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: HIV vaccine & Immune system. The author has an hindex of 15, co-authored 24 publications receiving 2762 citations. Previous affiliations of Erica Andersen-Nissen include Institute for Systems Biology & University of Washington.
Papers
More filters
Journal ArticleDOI
Integrated analysis of multimodal single-cell data
Yuhan Hao,Stephanie Hao,Erica Andersen-Nissen,William M. Mauck,Shiwei Zheng,Andrew Butler,Maddie Jane Lee,Aaron J. Wilk,Charlotte A. Darby,Michael Zager,Paul Hoffman,Marlon Stoeckius,Efthymia Papalexi,Eleni P. Mimitou,Jaison Jain,Avi Srivastava,Tim Stuart,Lamar M. Fleming,Bertrand Z. Yeung,Angela J. Rogers,Juliana M. McElrath,Catherine A. Blish,Raphael Gottardo,Peter Smibert,Rahul Satija +24 more
TL;DR: Weighted-nearest neighbor analysis as mentioned in this paper is an unsupervised framework to learn the relative utility of each data type in each cell, enabling an integrative analysis of multiple modalities.
Posted ContentDOI
Integrated analysis of multimodal single-cell data
Yuhan Hao,Stephanie Hao,Erica Andersen-Nissen,William M. Mauck,Shiwei Zheng,Andrew Butler,Maddie Jane Lee,Aaron J. Wilk,Charlotte A. Darby,Michael Zagar,Paul Hoffman,Marlon Stoeckius,Efthymia Papalexi,Eleni P. Mimitou,Jaison Jain,Avi Srivastava,Tim Stuart,Lamar Ballweber Fleming,Bertrand Z. Yeung,Angela J. Rogers,Juliana M. McElrath,Catherine A. Blish,Raphael Gottardo,Peter Smibert,Rahul Satija +24 more
TL;DR: ‘weighted-nearest neighbor’ analysis is introduced, an unsupervised framework to learn the relative utility of each data type in each cell, enabling an integrative analysis of multiple modalities.
Journal ArticleDOI
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility.
Kelly D. Smith,Kelly D. Smith,Erica Andersen-Nissen,Erica Andersen-Nissen,Fumitaka Hayashi,Fumitaka Hayashi,Fumitaka Hayashi,Katie Strobe,Molly A. Bergman,Sara L. Rassoulian Barrett,Brad T. Cookson,Alan Aderem +11 more
TL;DR: The exquisite ability of the innate immune system to precisely target a conserved site on flagellin that is essential for bacterial motility is demonstrated.
Journal ArticleDOI
Evasion of Toll-like receptor 5 by flagellated bacteria.
Erica Andersen-Nissen,Kelly D. Smith,Katie Strobe,Sara L. Rassoulian Barrett,Brad T. Cookson,Susan M. Logan,Alan Aderem +6 more
TL;DR: The results suggest that TLR5 evasion is critical for the survival of this subset of bacteria at mucosal sites in animals and raise the intriguing possibility that flagellin receptors provided the selective force to drive the evolution of these unique subclasses of bacterial flageLLins.
Journal ArticleDOI
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
Edward A. Miao,Erica Andersen-Nissen,Erica Andersen-Nissen,Sarah E. Warren,Sarah E. Warren,Alan Aderem +5 more
TL;DR: In macrophages infected with Salmonella typhimurium or Legionella pneumophila, Ipaf becomes activated in response to flagellin that appears to be delivered to the cytosol via specific virulence factor transport systems.